TLDR Wnt-10b helps skin cells and hair grow.
The study investigated the role of Wnt-10b, a protein secreted by activated lymphocytes, in the differentiation of skin epithelial cells and hair follicle development. It was found that Wnt-10b mRNA was expressed in Con A-stimulated lymphocytes and mouse embryonic stem cells, but not in unstimulated lymphocytes. The research highlighted the unique role of Wnt-10b in promoting epithelial differentiation and hair shaft growth, which was previously underexplored due to the unavailability of commercial Wnt-10b protein. The study used inbred female C3H/HeN mice and demonstrated that Wnt-10b activates the canonical pathway, enhancing the differentiation of immature epithelial cells into hair shaft and IRS lineages.
36 citations
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February 2006 in “Biochemical and Biophysical Research Communications” Wnt-10b helps skin cells develop into hair-related structures.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
13 citations
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November 2003 in “Humana Press eBooks” ES cells can be turned into hair follicle cells in a lab setting.
297 citations
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January 2002 in “Development” Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.
139 citations
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July 1991 in “Journal of The American Academy of Dermatology” Understanding hair follicle anatomy helps diagnose hair disorders.
128 citations
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March 1989 in “Experimental Cell Research” Hoxc13 is important for hair and tongue development by controlling hair keratin genes.
356 citations
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December 1986 in “The journal of cell biology/The Journal of cell biology” Hair and nail cells share similar proteins, indicating a common differentiation pathway.
February 2024 in “ACS applied bio materials” Keratin microspheres might help hair grow.
50 citations
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July 2008 in “British Journal of Dermatology” 138 citations
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March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
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January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
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January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
