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    Did you mean Prostaglandin D2 Synthase?
    Glossary Prostaglandin D2 Synthase

    enzyme converting prostaglandin H2 to prostaglandin D2, linked to hair loss

    Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin H2 into prostaglandin D2 (PGD2), a lipid compound involved in various physiological processes, including inflammation and allergic responses. In the context of hair biology, elevated levels of PGD2 have been linked to hair loss, particularly in conditions like androgenetic alopecia.

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    1. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997 · 81 citations
    2. The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A Scientific Reports · 2020 · 20 citations
    3. A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning Journal of Cutaneous Pathology · 2013 · 6 citations
    4. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss Journal of Ethnopharmacology · 2015 · 30 citations
    5. Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D<sub>2</sub> synthase expression in adult rats Toxicology and Industrial Health · 2015 · 14 citations
    6. Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS) Science-business Exchange · 2012 · 2 citations
    7. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase Journal of Lipid Research · 2013 · 20 citations
    8. Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin Frontiers in Physiology · 2021 · 18 citations
    9. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase Acta Crystallographica Section D-biological Crystallography · 2014 · 5 citations
    10. Computer-Aided Designing Peptide Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase Combined Molecular Docking and Molecular Dynamics Simulation Molecules · 2023 · 9 citations
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    1. Painkillers May Block Minoxidil Reddit · 20 Mar 2025
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