Effectiveness of Combined Oral Minoxidil and Finasteride in Male Androgenetic Alopecia: A Retrospective Service Evaluation

    January 2025 in “ Cureus
    Hans Johnson, David T. Huang, Ashley K. Clift, Ângela Cristine Bersch-Ferreira, Gustavo Cardoso Guimarães
    From the encyclopedia
    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

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    Studysummary The researchers reported that a combined oral minoxidil-finasteride regimen significantly improved hair density in men with androgenetic alopecia over 12 months, although further confirmation in different trials is suggested.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study involving 502 men with male androgenetic alopecia found that a combined oral minoxidil-finasteride regimen significantly improved hair density over 12 months, with 92.4% of participants experiencing stable or improved hair density and 57.4% showing marked improvements. Even severe cases showed substantial gains, suggesting the treatment's effectiveness beyond mild cases. Despite positive outcomes, the study's retrospective design and modest inter-rater reliability highlight the need for more rigorous trials to confirm findings and optimize treatment protocols. Future research should focus on incorporating patient-reported outcomes and AI-driven methods for better assessment accuracy.
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