Exploring the Role of CYP19A1 Single Nucleotide Polymorphisms in the Pathogenesis of Female Pattern Hair Loss

May 2025 in “ Egyptian Journal of Dermatology and Venerology ”

Nashwa E. Ahmed, Ghada M. Shams, Omnia Babekir Abdallah, Adel El-Kholy, Manar G. Abd Elrazik, Shaymaa M. Abdelrahman

CYP19A1 female pattern hair loss FPHL single nucleotide polymorphisms rs184895853 rs116904472 DHEAS testosterone estradiol hormonal component polycystic ovary syndrome acne hirsutism androgen levels female pattern baldness hormones androgens

TLDR Certain gene changes and hormone levels are linked to female hair loss.

This study examined the link between CYP19A1 gene polymorphisms and female pattern hair loss (FPHL) in 180 Egyptian women, including 120 FPHL patients and 60 controls. It found that FPHL patients had significantly higher CYP19A1 gene expression and different frequencies of the rs184895853 and rs116904472 polymorphisms compared to controls, suggesting a genetic association with FPHL. Additionally, FPHL patients showed elevated levels of hormones like DHEAS, testosterone, and estradiol, indicating a hormonal component in FPHL's pathogenesis. The study also noted a potential connection between FPHL and polycystic ovary syndrome phenotypes, as FPHL patients had higher rates of acne, hirsutism, and elevated androgen levels.

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