Exploring the Role of CYP19A1 Single Nucleotide Polymorphisms in the Pathogenesis of Female Pattern Hair Loss
May 2025
in “
Egyptian Journal of Dermatology and Venerology
”

TLDR Certain gene changes and hormone levels are linked to female hair loss.
This study examined the link between CYP19A1 gene polymorphisms and female pattern hair loss (FPHL) in 180 Egyptian women, including 120 FPHL patients and 60 controls. It found that FPHL patients had significantly higher CYP19A1 gene expression and different frequencies of the rs184895853 and rs116904472 polymorphisms compared to controls, suggesting a genetic association with FPHL. Additionally, FPHL patients showed elevated levels of hormones like DHEAS, testosterone, and estradiol, indicating a hormonal component in FPHL's pathogenesis. The study also noted a potential connection between FPHL and polycystic ovary syndrome phenotypes, as FPHL patients had higher rates of acne, hirsutism, and elevated androgen levels.