Early Onset Female Pattern Hair Loss: A Case-Control Study for Analyzing Clinical Features and Genetic Variants

February 2022 in “ Journal of Dermatological Science ”

Jungyoon Ohn, Ho Young Son, Da Yu, Min-su Kim, Sijin Kwon, Won Soon Park, Dong-Hyun Kim, Oh Sang Kwon

female pattern hair loss androgen-related features scalp greasiness folliculitis hirsutism polycystic ovary syndrome scalp pain itching single nucleotide polymorphisms PPARGC1A ABCC4 CYP19A1 eFPHL SNPs PCOS

TLDR Early onset female hair loss is linked to lower hair density, scalp issues, and certain genetic factors.

This study investigated early onset female pattern hair loss (eFPHL) by comparing 63 patients with eFPHL to 341 controls. It found that eFPHL is characterized by decreased hair shaft density and cross-sectional area, and is associated with androgen-related features such as scalp greasiness, folliculitis, hirsutism, and polycystic ovary syndrome. Patients also reported more frequent scalp pain and itching. Genetic analysis identified 49 significant single nucleotide polymorphisms (SNPs) around genes like PPARGC1A, ABCC4, and CYP19A1, with two notable SNPs in PPARGC1A. The study suggests these findings could help understand the pathology of eFPHL, but emphasizes the need for larger studies due to the limited sample size.

View this study on jdsjournal.com →

Discuss this study in the Community →

Research cited in this study

32 / 32 results

research Female Pattern Hair Loss in Men: A Distinct Clinical Variant of Androgenetic Alopecia

5 citations , September 2020 in “Journal of The American Academy of Dermatology”

Men can experience female pattern hair loss, needing different treatments.

research Spironolactone for Treatment of Female Pattern Hair Loss

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

Spironolactone effectively treats female pattern hair loss with few side effects.

research PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology

24 citations , November 2019 in “Experimental Dermatology”

PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.

research Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia

8 citations , June 2019 in “Scientific Reports”

Increased PPARGC1α relates to hair thinning in common baldness.

research HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome

7 citations , May 2019 in “Journal of the Formosan Medical Association”

HSD3B1 gene variant and being overweight linked to hair loss in women with polycystic ovary syndrome.

research Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods

28 citations , March 2019 in “Journal of Dermatological Science”

The document concludes that while lab results for hair growth promotion are promising, human trials are needed and better testing methods should be developed.

research Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

43 citations , April 2017 in “Experimental Dermatology”

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

research A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

47 citations , June 2016 in “JAMA Dermatology”

Men with early hair loss have similar hormone levels to women with PCOS, possibly increasing risk of obesity and heart issues.

research Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss in a Han Chinese Population

5 citations , January 2016 in “Dermatology”

No significant link between CAG repeat numbers and female pattern hair loss in Han Chinese population.

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations , January 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle

25 citations , November 2014 in “British Journal of Dermatology”

Certain transporters are found in human hair follicles and may affect hair growth and loss.

research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation

28 citations , November 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

research Characteristic Features of Ageing in Korean Women's Hair and Scalp

31 citations , December 2012 in “British Journal of Dermatology”

Korean women's hair thins, weakens, and greys with age, with mineral and sterol changes.

research Factors Associated With Female Pattern Hair Loss And Its Prevalence In Taiwanese Women: A Community-Based Survey

33 citations , November 2012 in “Journal of The American Academy of Dermatology”

FPHL common in Taiwanese women; risk factors include BMI, high glucose, early puberty, fewer childbirths, oral contraceptives, and UV exposure.

research Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

9 citations , November 2012 in “Archives of Dermatological Research”

MC4R gene variants not linked to female hair loss.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations , February 2012 in “British Journal of Dermatology”

AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.

research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

27 citations , October 2011 in “British Journal of Dermatology”

ESR2 gene variations may be linked to female pattern hair loss.

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations , May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating TRPV3 stops human hair growth.

research Female Pattern Hair Loss in a Patient with 17α-Hydroxylase Deficiency

4 citations , January 2010 in “Acta dermato-venereologica”

Low androgen levels can still cause female pattern hair loss.

research Hypertension and Aldosterone Levels in Women with Early-Onset Androgenetic Alopecia

45 citations , November 2009 in “British Journal of Dermatology”

Women with early hair loss have higher blood pressure and aldosterone; screening and treatment may help.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , April 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research Androgenetic Alopecia in Adolescents: A Report of 43 Cases

35 citations , October 2006 in “Journal of Dermatology”

Teen hair loss common in boys, linked to family history and mild symptoms.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

174 citations , April 2005 in “The American journal of pathology (Print)”

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

research Androgenetic Alopecia in Children: Report of 20 Cases

72 citations , March 2005 in “British Journal of Dermatology”

AGA can occur in children with family history; early diagnosis and treatment important.

research Female Pattern Hair Loss

226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

157 citations , July 2001 in “British Journal of Dermatology”

AGA more common in men, Koreans have lower rates and unique patterns.

research Scalp Dysesthesia: A Study on Chronic Pain and Itchiness

63 citations , March 1998 in “Archives of Dermatology”

Antidepressants may improve or resolve scalp dysesthesia in most patients.

research Plasma C19 Steroid Sulfate Levels and Indices of Androgen Bioavailability in Female Pattern Androgenic Alopecia

32 citations , January 1990 in “Clinical Endocrinology”

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Related Research

7 / 7 results

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

1 citations , October 2022 in “PubMed”

Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.

research Early Onset Female Pattern Hair Loss: A Case-Control Study for Analyzing Clinical Features and Genetic Variants

3 citations , February 2022 in “Journal of Dermatological Science”

Early onset female hair loss is linked to lower hair density, scalp issues, and certain genetic factors.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Male Pattern Baldness: An Update

January 2009 in “Revista de Ciências Médicas”

Male pattern baldness is a genetic condition causing hair loss, with limited but improving treatment options.

research Hair and Scalp Diseases

12 citations , February 2008 in “CRC Press eBooks”

The document explains different hair and scalp conditions and their treatments.

The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

research The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

17 citations , October 2003 in “Brazilian Journal of Medical and Biological Research”

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.