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In this study, using EMLA cream did not adequately control pain during and after scalp PRP injections for androgenetic alopecia, with anxiety and younger age linked to higher pain levels.

This retrospective study found that applying local skin precooling before scalp nerve block significantly reduced injection site pain during PRP mesotherapy for patients with androgenetic alopecia, compared to those who did not receive precooling, thus improving patient comfort and compliance.

This study found that topical liquid nitrogen improved pain tolerance during intradermal platelet-rich plasma therapy in androgenic alopecia compared to normal saline, although patient satisfaction did not significantly differ between groups.

This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.

The authors suggest that scalp pain resulting from infestations, infections, or inflammatory diseases should be included in the next classification of headaches, as it currently lacks clear clinical characteristics and inclusion in the ICHD-3 criteria.