Genotypes of Single-Nucleotide Polymorphisms on DENND1A in Association with Polycystic Ovary Syndrome Among Saudi Arabian Females

July 2025

Hana Hakami, Saleh Alzahrani, Jawaher Al‐Zahrani, Mazin H. Daghestani, Maha H. Daghestani

TLDR SNP rs2479106 in the DENND1A gene may increase PCOS risk in Saudi Arabian females.

This study investigated the association of three single-nucleotide polymorphisms (SNPs) in the DENND1A gene with polycystic ovary syndrome (PCOS) among Saudi Arabian females. The research included 36 normally cycling and 33 PCOS females, analyzing SNPs rs10818854, rs2479106, and rs10986105. The findings revealed a significant association between SNP rs2479106 and PCOS, while no such association was found for rs10818854 and rs10986105. This suggests that rs2479106 may be a genetic risk factor for PCOS in this population.

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research The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

767 citations , September 2016 in “Human Reproduction”

Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.

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258 citations , July 2016 in “Reproductive Biology and Endocrinology”

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

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926 citations , June 2010 in “BMC Medicine”

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

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286 citations , January 2009 in “Human Reproduction Update”

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

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4025 citations , December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

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1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.