Genotypes of Single-Nucleotide Polymorphisms on DENND1A in Association with Polycystic Ovary Syndrome Among Saudi Arabian Females

    July 2025
    Hana Hakami, Saleh Alzahrani, Jawaher Al‐Zahrani, Mazin H. Daghestani, Maha H. Daghestani
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    TLDR SNP rs2479106 in the DENND1A gene may increase PCOS risk in Saudi Arabian females.
    This study investigated the association of three single-nucleotide polymorphisms (SNPs) in the DENND1A gene with polycystic ovary syndrome (PCOS) among Saudi Arabian females. The research included 36 normally cycling and 33 PCOS females, analyzing SNPs rs10818854, rs2479106, and rs10986105. The findings revealed a significant association between SNP rs2479106 and PCOS, while no such association was found for rs10818854 and rs10986105. This suggests that rs2479106 may be a genetic risk factor for PCOS in this population.
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