Pathophysiology of Androgenetic Alopecia and Implications for Treatment: An Overview of Current Literature

    Neha Iska, Esther Nwozo, Hafsa Hassan … Kelly Frasier
    Studysummary Androgenetic alopecia treatments focus on reducing hair loss by targeting hormones, with new therapies showing promise but needing more research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 70

    1. A Clinical Evaluation of the Safety, Efficacy, and Tolerability of the Soulflower Rosemary Redensyl Hair Growth Serum, Tetragain, in Healthy Female Subjects for the Treatment of Alopecia: Promoting Hair Growth and Reducing Gray Hair Cureus · 2025
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    3. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    4. Side Effects’ Frequency Assessment of Low Dose Oral Minoxidil in Male Androgenetic Alopecia Patients Skin Appendage Disorders · 2024
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    6. Finasteride and Dutasteride for the Treatment of Male Androgenetic Alopecia: A Review of Efficacy and Reproductive Adverse Effects Georgetown medical review · 2023
    7. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    8. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Medicine · 2023
    9. The Efficacy and Safety of Oral Spironolactone in the Treatment of Female Pattern Hair Loss: A Systematic Review and Meta-Analysis Cureus · 2023
    10. A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle Plastic and Reconstructive Surgery · 2023
    11. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    12. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    13. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    14. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    15. Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Frontiers in Medicine · 2022
    16. Long-Term Effectiveness and Safety of Dutasteride Versus Finasteride in Patients With Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study Annals of Dermatology · 2022
    17. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    18. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    19. Proposed Mechanisms of Low-Level Light Therapy in the Treatment of Androgenetic Alopecia Lasers in Medical Science · 2020
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    21. The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial Journal of The American Academy of Dermatology · 2020
    22. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    23. Topical Ketoconazole for the Treatment of Androgenetic Alopecia: A Systematic Review Dermatologic Therapy · 2019
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    25. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    26. Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels Journal of The American Academy of Dermatology · 2018
    27. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    28. Controversies in Hair Transplantation Journal of cutaneous and aesthetic surgery · 2018
    29. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    30. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    31. Scalp Threading with Polydioxanone Monofilament Threads: A Novel, Effective, and Safe Modality for Hair Restoration Journal of The European Academy of Dermatology and Venereology · 2017
    32. Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia Expert Opinion on Investigational Drugs · 2017
    33. Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process Clinical, Cosmetic and Investigational Dermatology · 2017
    34. Male Pattern Baldness and Risk of Incident Skin Cancer in a Cohort of Men International Journal of Cancer · 2016
    35. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia Dermatologic Surgery · 2016
    36. Classifications of Patterned Hair Loss: A Review Journal of Cutaneous and Aesthetic Surgery · 2016
    37. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015
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    39. Progression of Surgical Hair Restoration Techniques Journal of Cutaneous Medicine and Surgery · 2015
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    44. Androgenetic Alopecia and Risk of Coronary Artery Disease Indian Dermatology Online Journal · 2013
    45. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
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    47. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    48. Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss Patients Journal of Dermatology · 2010
    49. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    50. Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash Growth Dermatologic Surgery · 2010
    51. Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome British Journal of Dermatology · 2010
    52. Diffuse Hair Loss: Its Triggers and Management Cleveland Clinic Journal of Medicine · 2009
    53. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    54. Dutasteride Drugs · 2008
    55. Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis Journal of Dermatological Science · 2004
    56. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    57. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    58. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    59. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
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    61. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    62. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    63. Incidence of Female Androgenetic Alopecia Dermatologic Surgery · 2001
    64. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    65. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    66. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
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    68. The Psychological Effects of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 1992
    69. Use of Spironolactone in the Treatment of Hirsutism Cleveland Clinic journal of medicine · 1990
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