Large-Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata

    December 2017 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Cecilia S. Lindestam Arlehamn, Sinu Paul, Eddy Hsi Chun Wang, Annemieke de Jong, Angela M. Christiano, Alessandro Sette
    TLDR The conclusion is that a new method could improve the identification of autoimmune targets in alopecia areata, despite some limitations.
    The document from 2018 discussed the development of an unbiased, large-scale screening method to identify antigen epitopes in autoimmune diseases, specifically focusing on alopecia areata (AA). It highlighted the limitations of traditional methods for identifying autoantigens and proposed the use of the Immune Epitope Database and Analysis Resource (IEDB) for high-throughput epitope prediction from hair follicle proteins. The goal was to validate these predictions using peripheral blood mononuclear cells from AA patients to identify true, disease-associated autoantigen epitopes. However, the document acknowledged that this method might not capture all disease-associated epitopes and could be biased toward certain cytokines and T-cell subsets. Despite these limitations, the document emphasized the potential of this approach to improve the identification and validation of autoantigen epitopes in AA.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community To anyone that is still not seeing results on the big 3…

      in Treatment  103 upvotes 3 years ago
      User redh0t12 suggests using a derma pen for hair regrowth, as it helped them after using finasteride and minoxidil. Others discuss their experiences with various treatments, including derma rolling, oral and topical minoxidil, and finasteride, with mixed results.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 1 year ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

      community Losing hair everywhere, idk what to do :(

       28 upvotes 6 years ago
      A 22-year-old male has been experiencing widespread hair loss for over four years, including pain and significant shedding. Treatments tried include ketoconazole shampoo, fluocinonide topical solution, biotin, ACV, and dry shampoo, but none have been effective.

    Related Research

    3 / 3 results