Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

January 2012 in “ Indian Journal of Dermatology, Venereology and Leprology ”

Ying Zhang, Bin Zhou, Sillani Caulloo, Xiaohong Chen, Li Yang, Xingqi Zhang

diffuse alopecia areata inflammatory infiltration CD8+ T cells serum IgE level patchy alopecia areata eosinophils hypersensitivity pathogenesis diffuse AA patchy AA IgE T cells

TLDR Diffuse alopecia areata involves more inflammation and higher allergy-related antibodies than patchy types.

The study compared 17 patients with diffuse alopecia areata (AA) to 37 with patchy AA and 27 healthy controls, revealing that diffuse AA is characterized by more intense inflammatory infiltration, especially by CD8+ T cells, and higher serum IgE levels. The average age of diffuse AA patients was 27, and their condition often began acutely in spring or summer, frequently following scalp itching. The increased infiltration and IgE levels suggest a hypersensitivity component in diffuse AA's pathogenesis. The presence of eosinophils was also noted as a potential diagnostic marker, although their exact role is unclear. The study's small sample size indicates a need for further research to better understand diffuse AA.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

in Treatment 42 upvotes 9 months ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.

community I’m 14 years old and I’m losing more hair than my dad. I’ve gone to the doctor 2 times because of this and I’ve received no help. I’m starting to feel like It’s worthless and my hairs gonna look like this forever. I don’t know how anyone could help me but it’s always worth a shot.

in Treatment 4 years ago

A 14 year old who is experiencing hair loss and has not received any help from the doctor, with advice being given to try different doctors, get tested for underlying conditions and intolerances, buzz it short as an option and treatments that could slow down or reverse the hair loss such as minoxidil, finasteride, RU58841 and addressing the cause of the hair loss.

community After Years of Treatment, I'm Shaving my Head and Giving Up

in Shaved/buzzed 119 upvotes 1 week ago

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community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

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