Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    July 2025 in “ Frontiers in Medicine
    Laura Ghanem, Nigar Kirmani, María Paula Palacios-Ortiz, Martin Cevallos‐Cueva, D Mendoza, Guilherme Fagundes Nascimento, Virginia Velasco‐Tamariz
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    TLDR Single-spin and double-spin PRP methods are equally effective for treating hair loss.
    This systematic review and meta-analysis compared single-spin and double-spin platelet-rich plasma (PRP) centrifugation methods in treating androgenic alopecia (AGA) across three randomized controlled trials with 90 participants. The study found no significant differences between the two methods in terms of final platelet concentration, hair density improvement, or changes in terminal and vellus hair counts. The pooled mean differences for these outcomes showed no statistical significance, indicating that neither centrifugation method had a clear advantage in enhancing hair growth. The analysis highlighted a high degree of heterogeneity in platelet concentration results, likely due to varying centrifuge settings, but no significant heterogeneity was observed in hair density and hair count outcomes. The quality assessment indicated a low risk of bias in most studies, although one study had some concerns regarding the selection of reported results.
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