Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    July 2025 in “ Frontiers in Medicine
    Laura Ghanem, Nigar Kirmani, María Paula Palacios-Ortiz, Martin Cevallos‐Cueva, D Mendoza, Guilherme Fagundes Nascimento, Virginia Velasco‐Tamariz
    Image of study
    TLDR Single-spin and double-spin PRP methods are equally effective for treating hair loss.
    This systematic review and meta-analysis compared single-spin and double-spin platelet-rich plasma (PRP) centrifugation methods in treating androgenic alopecia (AGA) across three randomized controlled trials with 90 participants. The study found no significant differences between the two methods in terms of final platelet concentration, hair density improvement, or changes in terminal and vellus hair counts. The pooled mean differences for these outcomes showed no statistical significance, indicating that neither centrifugation method had a clear advantage in enhancing hair growth. The analysis highlighted a high degree of heterogeneity in platelet concentration results, likely due to varying centrifuge settings, but no significant heterogeneity was observed in hair density and hair count outcomes. The quality assessment indicated a low risk of bias in most studies, although one study had some concerns regarding the selection of reported results.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 100 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  95 upvotes 4 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    6 / 1000+ results