Comparison of Single-Spin to Double-Spin Platelet-Rich Plasma Centrifugation Methods in the Treatment of Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    July 2025 in “ Frontiers in Medicine ”
    Laura Ghanem, Nigar Kirmani, María Paula Palacios-Ortiz … Virginia Velasco‐Tamariz
    Studysummary In this systematic review and meta-analysis, the authors examined single-spin versus double-spin centrifugation protocols for PRP in patients with androgenic alopecia and found no significant difference in platelet concentration, hair density, or hair types between the protocols.
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    Research cited in this study 22

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    4. Is Autologous Platelet-Rich Plasma Capable of Increasing Hair Density in Patients with Androgenic Alopecia? A Systematic Review and Meta-Analysis of Randomized Clinical Trials Anais Brasileiros de Dermatologia · 2024
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    6. Comparing Single-Spin Versus Double-Spin Platelet-Rich Plasma Centrifugation Methods on Thrombocyte Count and Clinical Improvement of Androgenetic Alopecia: A Preliminary, Randomized, Double-Blind Clinical Trial PubMed · 2023
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    9. Platelet-Rich Plasma in Androgenetic Alopecia: Is It Really Worth the Hype? International Journal of Trichology · 2023
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    12. Evaluation of the Safety and Efficacy of Platelet-Rich Plasma in the Treatment of Female Patients with Chronic Telogen Effluvium: A Randomized, Controlled, Double-Blind, Pilot Clinical Trial Indian Journal of Dermatology, Venereology and Leprology · 2022
    13. Different Platelet-Rich Plasma Preparation Protocols in Female Pattern Hair Loss: Does It Affect the Outcome? A Pilot Study Journal of Cosmetic Dermatology · 2022
    14. Platelet-Rich Plasma in Hair Loss—Mechanism, Preparation, and Classification Journal of Cosmetic Dermatology · 2021
    15. Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review Journal of Investigative Dermatology Symposium Proceedings · 2020
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    17. Androgenetic Alopecia Treatment in Asian Men PubMed · 2018
    18. Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia Aesthetic Plastic Surgery · 2017
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