Systematic Review of Platelet-Rich Plasma in Medical and Surgical Specialties: Quality, Evaluation, Evidence, and Enforcement

This systematic review evaluates the quality control measures and regulatory environment of platelet-rich plasma (PRP) treatments across various medical and surgical specialties, analyzing 75 randomized controlled trials involving 5726 patients. It highlights significant variability in PRP preparation methods and application techniques, proposing the William–Eqram Scoring System for PRP Quality Reporting (WESS-PQR) to address these inconsistencies. Findings show a strong positive correlation between proper temperature control during preparation and PRP efficacy, and a moderate positive correlation with initial platelet count assessment. The review concludes that standardized PRP preparation protocols and robust regulatory frameworks are urgently needed to ensure the safety and efficacy of PRP treatments.