Evaluation of the Effects of Adding an Adipose Tissue-Derived Stromal Vascular Fraction to Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: A Randomized Clinical Trial

    April 2024 in “ Skin research and technology
    Elham Behrangi, Seyyedeh Tahereh Rahimi, Samad Zare, Azadeh Goodarzi, Mohammadreza Ghassemi, Fariba Khodadad, Maryam Nouri, Samaneh Mozafarpoor, Abbas Dehghani, Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab
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    TLDR Adding stromal vascular fraction to platelet-rich plasma injections did not significantly improve hair growth in androgenetic alopecia treatment.
    The study involved 18 patients with androgenetic alopecia (AGA) and evaluated the effects of adding adipose tissue-derived stromal vascular fraction (SVF) to platelet-rich plasma (PRP) injections. The patients were divided into two groups: one received PRP injections and the other received SVF-PRP injections. Both treatments significantly increased hair count and hair diameter, with the mean hair count increase being 11.44 in the PRP group and 7.78 in the SVF-PRP group. However, the addition of SVF to PRP did not significantly enhance the treatment's effectiveness. The study suggested that the number of SVF injection sessions and the PRP preparation method could influence these results. It was hypothesized that for SVF to be more effective than PRP, it should be injected in multiple sessions. The study concluded that further research with larger sample sizes and more frequent SVF injections is needed.
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