Fat Grafting and Platelet-Rich Plasma for the Treatment of Diabetic Foot Ulcers: A Feasibility Randomized Controlled Trial

    July 2020 in “ International Wound Journal ”
    Oliver J. Smith, Richard Leigh, Muholan Kanapathy, Peter Macneal, Gavin Jell, Nadine Hachach‐Haram, H. A. MANN, Afshin Mosahebi
    Studysummary This study evaluated the feasibility of a single-center, three-arm trial to assess fat grafting with or without PRP for diabetic foot ulcers, finding high patient engagement and indicating that a multi-center trial could be safe and feasible.
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    This study assessed the feasibility of a randomized controlled trial (RCT) to evaluate fat grafting and platelet-rich plasma (PRP) for treating diabetic foot ulcers (DFU). Conducted as a single-center, three-arm trial, 18 patients were enrolled and divided equally among control, fat grafting, and fat grafting with PRP groups. Over 12 weeks, 28% of wounds healed, but no significant differences in clinical outcomes were observed between groups. The study confirmed the feasibility and safety of a multi-center RCT, with high patient engagement and no serious adverse events, providing valuable insights for future trial designs.
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