Fat Grafting and Platelet-Rich Plasma for the Treatment of Diabetic Foot Ulcers: A Feasibility Randomized Controlled Trial

This study assessed the feasibility of a randomized controlled trial (RCT) to evaluate fat grafting and platelet-rich plasma (PRP) for treating diabetic foot ulcers (DFU). Conducted as a single-center, three-arm trial, 18 patients were enrolled and divided equally among control, fat grafting, and fat grafting with PRP groups. Over 12 weeks, 28% of wounds healed, but no significant differences in clinical outcomes were observed between groups. The study confirmed the feasibility and safety of a multi-center RCT, with high patient engagement and no serious adverse events, providing valuable insights for future trial designs.