Transcriptomic Analysis of Human Skin Wound Healing and Rejuvenation Following Ablative Fractional Laser Treatment

The study investigated the effects of ablative fractional laser treatment on skin rejuvenation by analyzing gene expression changes in skin biopsies from 14 women. The research found significant alterations in gene expression as early as 1 day post-treatment, with sustained changes observed up to 28 days. These changes involved inflammatory, epidermal, and dermal genes, particularly those related to extracellular matrix formation. The study also noted that fractional laser treatment reversed many age-related gene expression changes. Multiple treatments enhanced dermal remodeling, indicating that repeated sessions are necessary for optimal skin rejuvenation. Overall, the treatment activated biological processes related to wound healing and tissue regeneration.