Adenosine as an Active Ingredient in Topical Preparations Against Hair Loss: A Systematic Review and Meta-Analysis of Published Clinical Trials

This systematic review and meta-analysis evaluated the efficacy of topical adenosine in treating hair loss by analyzing 7 clinical trials with 466 participants. The trials indicated that adenosine could reduce hair loss and increase hair density, although the evidence was rated from very low to moderate due to small sample sizes and flawed designs. A meta-analysis of 3 trials using 0.75% adenosine lotion showed a tendency for increased hair density and thickness and a decrease in thin hairs after 6 months, but differences from placebo were not statistically significant. Patient satisfaction was generally higher with adenosine compared to treatments like 5% minoxidil. Despite the low strength of evidence, adenosine may be beneficial, especially for those who cannot use approved hair loss medications, but further well-designed trials are needed to confirm these findings.