Caffeine as an Active Ingredient in Cosmetic Preparations Against Hair Loss: A Systematic Review of Available Clinical Evidence

In this review, the authors discuss caffeine's potential mechanisms and benefits as a hair loss treatment, noting its possible effectiveness and safety, though they caution that existing studies often have significant design flaws.

This study suggests that while some evidence indicates potential efficacy of placental products for hair growth and inhibiting hair loss, the current scientific evidence is scarce and of low quality.

This study found that while glucagon-like peptide 1 receptor agonists report more incidents of suicide, hair loss, and aspiration compared to some other antidiabetic drugs, they did not meet the threshold for positive safety signals.

This source provides an overview of different types of hair loss and their treatments, emphasizing the importance of comprehensive evaluation and patient education in managing conditions like androgenetic alopecia and alopecia areata, to address related psychological impacts and improve quality of life.

This review discusses how emerging technologies in dermatology are enhancing the ability to diagnose and treat hair and nail disorders more accurately and effectively, highlighting advancements in both diagnostic techniques and therapeutic methods such as AI-driven technologies that personalize patient care and improve outcomes.

This study analyzed adverse event reports from the FDA database and found that drugs such as immunomodulatory agents, monoclonal antibodies, minoxidil, contraceptives, and anti-TNF drugs are frequently associated with hair loss, suggesting guidance for dermatologists in identifying common medications linked to alopecia.

This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.

This study found that while caffeine and adenosine can inhibit hair loss and stimulate hair growth, more research is needed to fully understand the efficacy of shampoo formulations containing specific proportions of these compounds for hair loss treatment and prevention.

This case highlights the importance of considering syphilis testing for patients with unusual symptoms like hair loss and hypopigmentation, emphasizing the diagnostic and management challenges in resource-limited settings.

In this study, women with androgenetic alopecia underwent stem cell treatment, which led to significant improvements in sexual arousal and satisfaction, psychological health, and environmental quality of life, but not in physical health or social relationships after six months.

In this study analyzing trichological shampoos on the Polish market, researchers reported that most active ingredients claimed to combat hair loss were found in only one product each, questioning the scientific evidence supporting these claims.

In this study, 32 healthy adults with hair fall complaints applied a hair serum daily for 60 days, resulting in statistically significant improvements in hair growth rate, thickness, and density, without any reported adverse events.

This study found that a 12-week topical treatment with a caffeine and Procapil 3% formulation effectively reduced hair loss by 26.9% and improved hair growth in men with androgenetic alopecia, without any reported adverse effects.

This study found that a novel shampoo formulation effectively delivers caffeine to hair follicles, with 8–9% of absorbed caffeine reaching the follicles, suggesting it may support hair retention by enhancing antioxidant activity.

This review identified alopecia as a significant cosmetic side effect of antiseizure medications, particularly with valproate, lamotrigine, and carbamazepine, noting that hair loss often improves after dose adjustment.

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

This study reported that the novel topical serum REVIVV®, containing a blend of phytochemicals, significantly improved hair growth and reduced shedding in 150 participants with androgenetic alopecia after 8 weeks of use, while also being rated easy to use and prompting plans for continued use.

This study found a high discontinuation rate of topical minoxidil among patients with androgenetic alopecia, largely influenced by short treatment duration, lack of efficacy, and adverse effects.

This study found that a deep learning approach successfully predicted three types of hair and scalp diseases with high accuracy, despite challenges in dataset availability and image variety.

This study reports that various types of alopecia, including permanent alopecia, can persist after an acute DRESS episode, but telogen effluvium and alopecia areata showed clinical improvement with treatment within six months.

This study found that the HairComb algorithm achieved high accuracy in quantifying percentage hair loss across various types of alopecia, suggesting its potential for standardized automated assessments.

This review discusses the role of the Wnt/β-catenin pathway in hair follicle development and how natural products that activate this signaling could be used to treat hair loss, but it reports no new experimental results.

This article reviews in-vitro and cell-free methods for assessing the efficacy of herbal ingredients in cosmetic formulations for skin health and hair growth, but it reports no new clinical results.

This study found that collagen peptides from Mozambique tilapia significantly promoted hair regrowth and increased the proliferation of hair growth factors in vitro and in vivo, suggesting potential as supplements for hair loss prevention.

This review discusses androgenetic alopecia and alopecia areata through a systems biology perspective using omics technologies to explore molecular mechanisms and potential personalized therapies, and it reports no new clinical results.

This review highlights that androgenetic alopecia significantly impacts psychological well-being and quality of life, emphasizing the need for integrated psychological support alongside dermatological treatment.

This study analyzed deep learning's application to automate hair density measurement in images and found that YOLOv4 had the best performance among tested algorithms, with a mean average precision of 58.67.

This study suggests that hormonal changes may contribute to the persistent symptoms of long COVID, with specific patterns observed in serum hormone levels related to fatigue and sensory dysfunction.

This study found that a refined wash test can effectively differentiate shedding hair characteristics among normal individuals, and patients with androgenetic alopecia or telogen effluvium, aiding in diagnosis and monitoring.

This study found that for people with androgenetic alopecia, increasing the dosage of low-dose oral minoxidil is associated with improvements in hair diameter and density, but also raises the risk of hypertrichosis and cardiovascular adverse events.

This study developed a deep learning framework and quantitative model that accurately predict basic and specific classification in male androgenetic alopecia by analyzing trichoscopic images.

This study demonstrated that a new non-invasive method for collecting and analyzing mouse hair follicles could replace traditional biopsy methods, providing advantages for translational research and routine applications.

This review discusses treatment options for androgenetic alopecia, highlighting the need for personalized, evidence-based approaches but reports no new clinical results.

This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.

This article proposes a machine learning framework for classifying healthy hair and alopecia areata using image processing and classification techniques, but does not report new clinical findings.

This review discusses excessive hair loss as a common symptom of COVID-19 infection, affecting both men and women regardless of age or other health conditions, but reports no new results.

This study found that a cosmetic foam reduced the telogen rate in men with androgenetic alopecia, suggesting a potential benefit against male pattern hair loss.

This study found that KY19382 can effectively promote hair regeneration and follicle neogenesis in mice and human hair models by activating Wnt/β-catenin signalling, suggesting potential use for alopecia treatment.

This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.

This study found that alopecia areata significantly impacts emotional and psychological well-being, relationships, and lifestyles, highlighting the need for increased awareness and effective treatments.

This review discusses the strengths and weaknesses of existing studies on complex dietary supplements for hair loss, emphasizing the need for valid measurement methods like TrichoScale® to quantify effectiveness; it reports no new results.

This review discusses pharmacologic and non-pharmacologic treatments for androgenetic alopecia, noting that current medications like finasteride and minoxidil can slow hair loss but only partially restore hair growth, with early treatment offering better outcomes.

In this in vitro study, niacinamide was found not to stimulate VEGF synthesis across a wide range of doses.

This review discusses the potential dermatological benefits of caffeine for hair growth, rosacea, and skin cancer, but notes significant limitations in available research.

This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.

Formononetin, found in red clover, may treat hair loss with fewer side effects.

This study found that negative social attractiveness ratings for bald men by same-aged women occurred only when individuating information about the target was absent, while the physical attractiveness stereotype remained active at an implicit level.

This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.

This study found that patients with androgenetic alopecia reported more impact on their quality of life in terms of emotions, functioning, and symptoms than those with alopecia areata.

This study found that a herbal shampoo and solution were more effective than placebo in reducing hair loss and improving hair growth in participants with androgenetic alopecia and telogen effluvium.

Taking 5 mg/day finasteride can cause side effects in women with hair loss, but these are usually mild and fade over time, making the treatment beneficial in the long run.

This study observed that nicotinamide can effectively inhibit human hair growth and promote hair follicle regression in cultured human scalp models without negatively affecting epidermal vitality, suggesting its potential as a hair growth inhibitor in cosmetic applications.

In this noninferiority study, researchers found that a 0.2% caffeine-based topical liquid was not less effective than 5% minoxidil solution in improving hair growth in men with androgenetic alopecia over six months.

This review discusses the classification and diagnosis of primary scalp alopecia, focusing on scarring and non-scarring types, and reports no new clinical results; it emphasizes simplified diagnostic pathways and tissue processing techniques.

This paper reviews seven major systemic causes of hair loss and provides a clinical evaluation framework but reports no new experimental results.

This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.

In this study, human placenta extract was observed to enhance the hair-growth-promoting effects of minoxidil and stimulate earlier and prolonged anagen phases in a mouse model.

This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.

This article discusses different types of hair loss, their potential causes, and treatment options, but it reports no new clinical findings; the authors emphasize the importance of considering the emotional impact on patients.

This study reports that hair growth and shedding in healthy women show annual seasonal patterns, with the highest shedding in summer and a less pronounced peak in spring.

This review discusses the advantages and limitations of various hair loss evaluation methods but reports no new results; it emphasizes the importance of cautious interpretation for these diagnostic tools.

In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.

This review discusses various techniques for evaluating hair shedding and alopecia but reports no new clinical results. The authors emphasize the value of specific clinical and instrumental methods in assessing hair growth.

This review discusses various methods for measuring scalp hair growth in androgenetic alopecia and reports no new results; the authors suggest that computer-assisted technology has untapped potential.