Hormonal Trends in Patients Suffering from Long COVID Symptoms

    January 2022 in “ Endocrine journal ”
    Naruhiko Sunada, Hiroyuki Honda, Yasuhiro Nakano, Koichiro Yamamoto, Kazuki Tokumasu, Yasue Sakurada, Yui Matsuda, Tomohiko Hasegawa, Yuki Otsuka, Mikako Obika, Yoshihisa Hanayama, Hideharu Hagiya, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka
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    TLDR Long COVID patients may have hormonal imbalances linked to their symptoms.
    This study conducted at Okayama University Hospital analyzed medical records and laboratory data of 186 patients who visited the outpatient clinic for long COVID from February to December 2021. The research aimed to investigate the hormonal profiles associated with long COVID symptoms. The results showed that patients with general fatigue had higher levels of serum cortisol and free thyroxin (FT4), and lower levels of serum growth hormone. Those with dysosmia/dysgeusia had significantly lower serum cortisol levels. Additionally, patients with a history of severe COVID-19 had higher serum thyrotropin (TSH) levels and lower FT4/TSH ratios, indicating potential subclinical hypothyroidism. The study also found that patients with higher SARS-CoV-2 antibody titers had decreased plasma adrenocorticotropin to serum cortisol ratios. These findings suggest that hormonal imbalances may contribute to the persistent symptoms experienced by long COVID patients.
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