Growth Hormone Deficiency with Late-Onset Hypothalamic Hypoadrenocorticism Associated with Respiratory and Renal Dysfunction: A Case Report

    April 2020 in “ BMC endocrine disorders ”
    Nami Kojima, Nobuyuki Koriyama, Akinori Tokito, Kazuma Ogiso, Koshi Kusumoto, Satoshi Kubo, Yoshihiko Nishio
    TLDR A woman with childhood growth hormone deficiency had multiple hormone deficiencies and developed serious lung and kidney problems later in life.
    This case report described a 65-year-old woman with childhood-onset growth hormone deficiency (GHD) who developed combined pituitary hormone deficiency (CPHD) over time, including late-onset secondary hypoadrenocorticism in her 60s, along with severe respiratory and renal dysfunction. The patient had an empty sella turcica and other risk factors for progression from isolated GHD to CPHD. Despite GH-replacement therapy, her respiratory and renal conditions did not improve, likely due to insufficient GH administration. The report highlighted the importance of lifelong endocrinological monitoring in GHD patients with risk factors for CPHD progression. The study also noted the rarity of ACTH deficiency onset in the 60s and the need for further evaluation of this phenomenon.
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