Hair Loss After Drug Reaction With Eosinophilia and Systemic Symptoms: A Multicentric Retrospective Case Series

    January 2023 in “ Journal of Dermatology ”
    Ji Won Lee, Duk Jun Yu, Soyun Cho, Sang Woong Youn, Oh Sang Kwon
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    TLDR Some types of hair loss can continue for a long time after recovering from a severe drug reaction known as DRESS.
    The study "Hair loss after drug reaction with eosinophilia and systemic symptoms (DRESS): A multicentric retrospective case series" reviewed the records of 182 patients diagnosed with DRESS from 2009 to 2021, and included 10 who had alopecia after DRESS. The patients were diagnosed with permanent alopecia (4), telogen effluvium (5), and alopecia areata (1), and were treated with topical minoxidil or alfatradiol (6; 60%), topical corticosteroids (3; 30%), dietary supplements (6; 60%), systemic corticosteroids (1; 10%), and intralesional corticosteroid injection (2; 20%). The study found that patients with permanent alopecia did not show hair regrowth after 6 months, while those with telogen effluvium and alopecia areata experienced marked clinical improvement within 6 months. The study concluded that various types of alopecia can persist over an extended period, even after the resolution of an acute episode of DRESS.
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