Genetic Differences Between Male and Female Pattern Hair Loss in a Korean Population

    July 2024 in “ Life
    Ji‐Hyun Lee, Ja‐Eun Choi, Joohun Ha, Young-Joo Kim, Chang Hyun Lee, Kyung‐Won Hong
    TLDR Certain genes may influence hair loss differently in men and women.
    This study analyzed 1,004 individuals (436 males and 568 females) to identify sex-specific genetic factors in androgenetic alopecia (AGA) in a Korean population. Genome-wide association studies (GWAS) identified three novel loci (rs7814359, rs2163085, and rs4793158) associated with hair loss. The SNP rs7814359 was significant in the combined sex group, rs2163085 was notably significant in females, and rs4793158 had a suggestive association in both groups. The genes TSNARE1, FZD1, and GJC1, linked to these SNPs, are involved in vesicle transport, Wnt signaling, and gap junctions, respectively. The findings suggest that sex hormones, such as estrogen, may influence female pattern hair loss (FPHL) through these genes, highlighting distinct genetic determinants and different underlying pathological mechanisms between the sexes.
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