Evaluation of Polyacrylonitrile Nonwoven Mats and Silver-Gold Bimetallic Nanoparticle-Decorated Nonwoven Mats for Potential Promotion of Wound Healing In Vitro and In Vivo and Bone Growth In Vitro
February 2021
in “
Polymers
”
Studysummary This study found that urchin-like Ag–Au bimetallic and Ag nanoparticle-decorated PAN mats showed significant antibacterial effects and potential for wound healing in in vitro and in vivo animal models.
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The study developed polyacrylonitrile (PAN) nonwoven mats combined with silver-gold (Ag-Au) bimetallic nanoparticles to enhance wound healing and bone growth. The PAN mats provided a stable substrate, while the nanoparticles offered antimicrobial properties and facilitated cell migration. In vitro and in vivo tests showed the mats' potential in treating musculoskeletal trauma, with effective antibacterial properties against S. aureus and E. coli, and no significant cytotoxicity or skin irritation. The mats supported osteoblast culture, indicating promise for bone tissue engineering. Statistical analyses confirmed significant results, suggesting these materials could be used for bone-integrating orthopedic implants and treating open fractures with soft tissue defects.
