Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules

    Hye-Ji Lee, Ha-Kyoung Kwon, Hye Su Kim, Moon Il Kim, Hye-Jin Park
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    TLDR PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
    The study explored the effects of 4HGF, an herbal mixture, when encapsulated with poly-γ-glutamic acid (PGA) nanoparticles, referred to as PGA-4HGF, on hair growth. The encapsulated 4HGF had an average size of ~400 nm and demonstrated a continuous release under simulated physiological conditions. In experiments with C57BL/6N mice, PGA-4HGF treatment led to increased hair length, earlier and prolonged anagen phase of hair growth, and enhanced dermal papilla cell proliferation. This was attributed to increased expression of β-catenin, cyclinD1, and CDK4 proteins, which are associated with cell cycle progression and hair cycle regulation. Additionally, PGA-4HGF increased the production of type II keratin proteins, essential for hair strength and structure. The study concluded that PGA-4HGF could be a potential therapeutic agent for hair growth disorders by promoting the transition from the telogen to anagen phase and activating hair growth-related pathways. The number of mice used in the study was not specified.
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