CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

April 2014 in “ Journal of Dietary Supplements ”

Hye-Jin Park

CARI ONE anagen phase telogen phase β-catenin dermal papilla cells melanogenesis Trp-1 proteins hair follicles minoxidil B16F10 cells growth phase resting phase Rogaine

Studysummary This study found that CARI ONE, a herbal mixture, promotes hair growth in mice by inducing the transition from telogen to anagen phase and enhancing hair follicle development, compared to control and minoxidil treatments. Our plain-language summary of this paper — not a Tressless recommendation.

In 2014, researchers studied the effects of CARI ONE, a blend of medicinal plants and mushrooms, on hair growth in telogenic C57BL/6N mice. The results showed that CARI ONE topically applied to the mice induced an earlier shift from the resting phase (telogen) to the growth phase (anagen) of hair follicles, extended the duration of the mature anagen phase, and increased both the number and size of hair follicles when compared to both a control group and a group treated with 1% minoxidil. Immunohistochemical analysis revealed an earlier increase in β-catenin and Trp-1 proteins in the hair follicles of the CARI ONE-treated mice. Additionally, in vitro tests demonstrated that CARI ONE enhanced the proliferation of dermal papilla cells and increased melanin production in B16F10 cells without compromising their viability. These findings indicate that CARI ONE may promote hair growth by triggering the anagen phase in dormant hair follicles.

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