Improved Poly (D,L-Lactide) Nanoparticles-Based Formulation for Hair Follicle Targeting

    January 2015 in “ International Journal of Cosmetic Science ”
    Bruno Fernandes, Raquel Silva, Artur Ribeiro, Teresa Matamá, Andreia C. Gomes, Artur Cavaco‐Paulo
    TLDR The improved nanoparticles can effectively target hair follicles for drug delivery.
    The study aimed to enhance the preparation of Poly (D,L-lactide) (PLA) nanoparticles for targeted drug delivery to hair follicles. Researchers used a nanoprecipitation method to create a monodispersed population of non-cytotoxic spherical nanoparticles approximately 150 nm in size, achieving a 90% yield. The nanoparticles effectively encapsulated and released both lipophilic and hydrophilic compounds, with entrapment efficiencies above 80%. Ex vivo skin penetration studies confirmed the presence of nanoparticles throughout the follicular ducts. The optimized method demonstrated potential for industrial-scale production of PLA nanoparticle-based formulations for hair follicle targeting, offering a promising approach for treating hair follicle-related disorders.
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