TLDR Encapsulating chlorogenic acid in nanoparticles boosts type 17 collagen production, potentially aiding skin care.
The study investigated the use of poly (lactide-co-glycolic acid) nanoparticles (PLGA NP) to enhance the production of type 17 collagen in human epidermal keratinocytes. Type 17 collagen is crucial for maintaining stem cells and preventing hair thinning. Chlorogenic acid (Cha) was identified as a promoter of type 17 collagen production, but it required high concentrations to be effective. The researchers encapsulated Cha in PLGA NP to improve its stability and delivery, resulting in a significant increase in type 17 collagen production in vitro. This suggested that PLGA NP could be a promising tool for developing effective skin care products, although further in vivo studies were needed.
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Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
