Leucine-Activated Nanohybrid Biofilm for Skin Regeneration via Improving Cell Affinity and Neovascularization Capacity

    January 2020 in “ Journal of Materials Chemistry B ”
    Xiajie Lin, Yamin Li, Wei Luo, Lan Xiao, Zeren Zhang, Jinzhong Zhao, Changsheng Liu, Yulin Li, Yulin Li, Yulin Li
    TLDR The biofilm enhances skin healing by promoting cell growth and blood vessel formation.
    The study developed a biodegradable nanofibrous biofilm incorporating leucine and LAPONITE® nanodisks to enhance skin regeneration by improving cell affinity and neovascularization. The biofilm was created by doping leucine, which aids fibroblast proliferation, into LAPONITE® nanodisks, which are rich in Mg and Si, promoting vascularization. These nanoparticles were combined with a polylactide (PLA) mesh, treated to improve hydrophilicity, thus enhancing cell affinity. The resulting biofilm supported fibroblast adhesion, migration, and proliferation, facilitating wound healing with blood vessel and hair follicle regeneration, attributed to its improved hydrophilicity and sustained leucine release.
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