Injectable Silk Nanofiber Hydrogels as Stem Cell Carriers to Accelerate Wound Healing

    January 2021 in “ Journal of Materials Chemistry B ”
    Jiadai Li, Zhaozhao Ding, Xin Zheng, Guozhong Lu, Qiang Lü, David L. Kaplan
    Image of study
    TLDR Silk nanofiber hydrogels help stem cells heal wounds faster and improve skin regeneration.
    In 2021, researchers developed an injectable silk nanofiber hydrogel to serve as a carrier for bone marrow derived mesenchymal stem cells (BMSCs) to enhance wound healing. The hydrogel provided a supportive environment for the growth and survival of stem cells, maintaining over 95% viability for at least 3 days. The hydrogel-stem cell combination significantly accelerated wound closure in a mouse model, improved collagen deposition, and promoted hair follicle regeneration. The hydrogels also increased the expression of wound healing-associated cytokines ANGPT-1 and HGF, while decreasing the expression of SDF-1 and VEGF-α. The study concluded that these silk nanofiber hydrogels were effective carriers for stem cells to accelerate wound healing, suggesting potential for further study in skin regeneration.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 45 results

      community Just passed by a homeless guy!

      in Chat  190 upvotes 2 months ago
      Hair loss treatments include finasteride, minoxidil, alfatradiol, vitamins, red light therapy, ketoconazole shampoo, meditation, green tea, leg workouts, and silk pillows. Genetics is emphasized as the primary factor in hair health, with some humor about unconventional methods like drug use affecting hair loss.

      community My Story + Products other than Finasteride and Minoxidil that saved me

      in Finasteride/Dutasteride  25 upvotes 1 year ago
      A user shared their hair loss journey, starting at age 18 and leading to depression and insecurity. They found improvement with finasteride and minoxidil after two years, and also recommended products like Mielle Rosemary Mint Growth Oil, Mielle Organics Rosemary Mint Strengthening Hair Masque, Kevin Murphy Hair Resort Spray, Brooklinen Silk Pillowcases, and It's a 10 Keratin Leave in Conditioner for maintaining hair quality.

      community General Advice for healthy hair: Tips and tricks?

      in Research/Science  10 upvotes 1 year ago
      The post and conversation are about hair loss treatments and tips for healthier hair, including using a dermaroller, taking vitamins (D, omega 3, zinc, magnesium), and using a silk pillowcase. The user also inquires about the effectiveness of aloe vera and oils for hair.

    Similar Research

    5 / 399 results