TLDR Silk nanofiber hydrogels help stem cells heal wounds faster and improve skin regeneration.
In 2021, researchers developed an injectable silk nanofiber hydrogel to serve as a carrier for bone marrow derived mesenchymal stem cells (BMSCs) to enhance wound healing. The hydrogel provided a supportive environment for the growth and survival of stem cells, maintaining over 95% viability for at least 3 days. The hydrogel-stem cell combination significantly accelerated wound closure in a mouse model, improved collagen deposition, and promoted hair follicle regeneration. The hydrogels also increased the expression of wound healing-associated cytokines ANGPT-1 and HGF, while decreasing the expression of SDF-1 and VEGF-α. The study concluded that these silk nanofiber hydrogels were effective carriers for stem cells to accelerate wound healing, suggesting potential for further study in skin regeneration.
8 citations,
January 2020 in “Biomaterials Science” Researchers developed a scaffold that releases a healing drug over time, improving wound healing and skin regeneration.
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145 citations,
November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
480 citations,
August 2014 in “Nature Biotechnology” Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
2 citations,
June 2023 in “Gels” Injectable hydrogels are becoming increasingly useful in medicine for drug delivery and tissue repair.
2 citations,
June 2023 in “Pharmaceutics” Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.
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8 citations,
May 2023 in “Gels” Chitosan hydrogels are promising for repairing blood vessels but need improvements in strength and compatibility.
119 citations,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
Peptide hydrogels show promise for healing skin, bone, and nerves but need improvement in stability and compatibility.
