Understanding Exosomes in Hair Regeneration

    July 2026 in “ Periodontology 2000 ”
    Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron
    Studysummary This study reviewed exosome-mediated interventions for alopecia, finding that they enhance hair regeneration by stimulating key pathways and improving hair properties, with clinical studies showing increased hair density and patient satisfaction, though further trials are needed for widespread clinical use.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 145

    1. Long-Term Efficacy and Safety of Low-Level Laser Therapy for Androgenetic Alopecia: A 12-Month Prospective Trial Dermatologic Therapy · 2026
    2. Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study Journal of Cosmetic Dermatology · 2025
    3. Androgenetic Alopecia Nature Reviews Disease Primers · 2025
    4. Advances in the Extracellular Vesicles Treatment of Alopecia Annals of Medicine · 2025
    5. Therapeutic Potential of Stem Cell-Derived Exosomes in Hair Regeneration: A Systematic Review World Journal of Stem Cells · 2025
    6. Topical Application of Bio-Pulsed Avian MSC-Derived Extracellular Vesicles Enhances Hair Regrowth and Skin Rejuvenation: Evidence from Clinical Evaluation and miRNA Profiling Current Issues in Molecular Biology · 2025
    7. Single-Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells-Derived Exosomes to Androgenetic Alopecia The FASEB Journal · 2025
    8. Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam Clinical Cosmetic and Investigational Dermatology · 2025
    9. Comparative Study on Therapeutic Efficacy of Minoxidil and Platelet-Rich Plasma Exosome in Androgenetic Alopecia Mice Models International Journal of Applied Pharmaceutics · 2025
    10. Enhancing Hair Regrowth Using Rapamycin-Primed Mesenchymal Stem Cell-Derived Exosomes Theranostics · 2025
    11. Enhancing Hair Regrowth in Pediatric Morphea En Coup De Sabre by Fractional CO2 Laser-Assisted Exosome Delivery Journal of Cosmetic Dermatology · 2025
    12. Subcutaneous Injection of Genetically Engineered Exosomes for Androgenic Alopecia Treatment Frontiers in Bioengineering and Biotechnology · 2025
    13. Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Androgenetic Alopecia World Journal of Stem Cells · 2025
    14. Successful Treatment of Hair Loss and Restoration of Natural Hair Color in Patient with Alopecia Areata Due to Psychological Disorder Using Exosomes: Case Report with 6-Month Follow-Up Cosmetics · 2025
    15. Local Corticosteroids for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    16. Platelet-Derived Extracellular Vesicles Promote Hair Follicle Growth Through Beta-Catenin Signaling Pathway Platelets · 2025
    17. Erythrocyte Extracellular Vesicles Integrate into Hair and Skin to Maintain Homeostasis Journal of Extracellular Vesicles · 2025
    18. Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Promote The Growth Of Human Hair Dermal Papilla Cells PubMed · 2025
    19. Mir-574-3p and Mir-125a-5p in Adipose-Derived Mesenchymal Stem Cell Exosomes Synergistically Target TGF-β1/Smad2 Signaling Pathway for the Treatment of Androgenic Alopecia Journal of Investigative Dermatology · 2025
    20. Alteration of Hair Growth in Mice by Circulating Exosomes from Xinji Fine-Wool and Small-Tailed Han Sheep Frontiers in Animal Science · 2025
    21. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    22. A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia Life · 2025
    23. Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia Journal of Controlled Release · 2025
    24. Achieving Sustained Hair Repigmentation in Poliosis Circumscripta: Retreatment Outcomes Using Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2025
    25. Novel Strategy for Hair Regeneration: Exosomes and Collagenous Sequences of Human A1(XVII) Chain Enhance Hair Follicle Stem Cell Activity by Regulating the Hsa-Novel-238a-CASP9 Axis Experimental Cell Research · 2025
    26. Decorin-Mediated Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Growth and Development Through miR-129-2-3p/SMAD3/TGF-β Axis International Journal of Biological Macromolecules · 2025
    27. Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling Clinical and Translational Medicine · 2025
    28. Exosomes as Crucial Mediators of Epithelial-Fibroblast Communication During Hair Follicle Morphogenesis in Cashmere Goats Comparative Biochemistry and Physiology Part D Genomics and Proteomics · 2024
    29. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway Journal of Translational Internal Medicine · 2024
    30. Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study Aesthetic Plastic Surgery · 2024
    31. Exosomes for Treating Hair Loss: A Review of Clinical Studies Dermatologic Surgery · 2024
    32. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    33. The Efficacy of Adipose Stem Cell-Derived Exosomes in Hair Regeneration Based on a Preclinical and Clinical Study International Journal of Dermatology · 2024
    34. Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment Journal of Controlled Release · 2024
    35. Stimulation of Mouse Hair Regrowth by Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Acta Histochemica · 2024
    36. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    37. Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment Pharmaceutics · 2024
    38. Rose Stem Cell-Derived Exosomes for Hair Regeneration Enhancement via Noninvasive Electroporation in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    39. The Roles of Exosomes in Regulating Hair Follicle Growth Clinical Cosmetic and Investigational Dermatology · 2024
    40. Compare The Efficacy Of PRP Intervention Vs Exosomes For Hair Loss: A Case Series Study 2024
    41. Hair Repigmentation of Poliosis Circumscripta in Androgenetic Alopecia Patient Treated With Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2024
    42. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview Biomolecules · 2023
    43. Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells Experimental Dermatology · 2023
    44. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    45. Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF Journal of Cosmetic Dermatology · 2023
    46. Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review Dermatology and Therapy · 2023
    47. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    48. Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report Heliyon · 2023
    49. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    50. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    51. Exosomes: The Latest in Regenerative Aesthetics Regenerative Medicine · 2023
    52. Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells International journal of molecular sciences · 2022
    53. Exosome Therapy for Scalp Hair Growth—A Review of the In Vivo and In Vitro Evidence Journal of the American Academy of Dermatology · 2022
    54. Ficoll Density Gradient Sedimentation Isolation of Pelage Hair Follicle Mesenchymal Stem Cells From Adult Mouse Back Skin: A Novel Method for Hair Follicle Mesenchymal Stem Cells Isolation Stem cell research & therapy · 2022
    55. Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles World journal of stem cells · 2022
    56. Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis Frontiers in Cell and Developmental Biology · 2022
    57. Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics Frontiers in cell and developmental biology · 2022
    58. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    59. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    60. Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities Journal of cosmetic dermatology · 2022
    61. Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Frontiers in Medicine · 2022
    62. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase Frontiers in Cell and Developmental Biology · 2022
    63. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    64. Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients Journal of cosmetic dermatology · 2022
    65. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022
    66. Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022
    67. Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study Aesthetic surgery journal · 2022
    68. Photobiomodulation Promotes Hair Regeneration in Injured Skin by Enhancing Migration and Exosome Secretion of Dermal Papilla Cells Wound repair and regeneration · 2021
    69. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    70. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    71. Engineered Extracellular Vesicle Mimetics from Macrophage Promotes Hair Growth in Mice and Human Hair Follicle Growth Experimental cell research · 2021
    72. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    73. Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration Tissue Engineering and Regenerative Medicine · 2021
    74. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021
    75. Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion Nutrients · 2021
    76. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    77. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    78. Exploring the Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021
    79. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    80. Male and Female Pattern Hair Loss: Treatable and Worth Treating Cleveland Clinic Journal of Medicine · 2021
    81. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    82. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    83. Dermatoscopic Evaluation of Central Centrifugal Cicatricial Alopecia Beyond the Vertex Scalp JAMA dermatology · 2020
    84. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cells Tissue Engineering and Regenerative Medicine · 2020
    85. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway Stem Cell Research & Therapy · 2020
    86. Follicular Unit Excision: A Hair Transplant Technique Facial Plastic Surgery Clinics of North America · 2020
    87. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    88. Old Friend or New Ally: A Comparison of Follicular Unit Transplantation and Follicular Unit Excision Methods in Hair Transplantation Dermatologic Surgery · 2020
    89. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    90. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    91. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    92. Contemporary Management of Alopecia: A Systematic Review and Meta-Analysis for Surgeons Aesthetic Plastic Surgery · 2019
    93. Exosome for Hair Regeneration: From Bench to Bedside Journal of the American Academy of Dermatology · 2019
    94. Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Stem cells · 2019
    95. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    96. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    97. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019
    98. Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019
    99. Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study Skin appendage disorders · 2019
    100. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    101. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    102. Platelet-Rich Plasma Therapy for Male and Female Pattern Hair Loss Dermatologic Surgery · 2018
    103. Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels Journal of The American Academy of Dermatology · 2018
    104. Shedding Light on the FDA’s 510(k) Approvals Process: Low-Level Laser Therapy Devices Used in the Treatment of Androgenetic Alopecia Journal of Dermatological Treatment · 2018
    105. Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Proposed Treatment Protocol International Journal of Women's Dermatology · 2018
    106. Hair Biology Facial Plastic Surgery Clinics of North America · 2018
    107. Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia Journal of The American Academy of Dermatology · 2018
    108. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018
    109. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    110. Cicatricial Alopecia: Overview and Treatment Recommendations Journal der Deutschen Dermatologischen Gesellschaft · 2018
    111. A Randomized Controlled, Single-Observer Blinded Study to Determine the Efficacy of Topical Minoxidil Plus Microneedling Versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia Journal of Cutaneous and Aesthetic Surgery · 2018
    112. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    113. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    114. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    115. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    116. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    117. Factors Affecting the Severity of Central Centrifugal Cicatricial Alopecia International Journal of Dermatology · 2016
    118. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    119. Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration World Journal of Stem Cells · 2015
    120. 5α-Reductase Inhibitors in Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2014
    121. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    122. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    123. The Human Hair: From Anatomy to Physiology International Journal of Dermatology · 2013
    124. Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings Journal of Investigative Dermatology Symposium Proceedings · 2013
    125. Analysis of Quantitative Changes in Hair Growth During Treatment With Chemotherapy or Tamoxifen in Patients With Breast Cancer: A Cohort Study British Journal of Dermatology · 2013
    126. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    127. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    128. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013
    129. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    130. Central Centrifugal Cicatricial Alopecia: Possible Familial Aetiology in Two African Families from South Africa International Journal of Dermatology · 2012
    131. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    132. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    133. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    134. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    135. Permanent Alopecia After Systemic Chemotherapy: A Clinicopathological Study of 10 Cases The American Journal of Dermatopathology · 2011
    136. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    137. Intralesional Steroids for Alopecia Areata International Journal of Trichology · 2010
    138. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    139. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    140. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    141. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    142. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    143. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    144. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    145. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987