Novel Strategy for Hair Regeneration: Exosomes and Collagenous Sequences of Human A1(XVII) Chain Enhance Hair Follicle Stem Cell Activity by Regulating the Hsa-Novel-238a-CASP9 Axis

    February 2025 in “ Experimental Cell Research ”
    Jingyu Zhao, Zhe Quan, Huiying Wang, Jun Wang, Yong Xie, J. Li, Jinpeng Lv
    TLDR Combining specific proteins and cell-derived particles may help treat hair loss.
    This study introduces a novel approach for hair regeneration by combining dermal papilla cell-derived exosomes (DPC-Exos) and collagenous sequences of Human a1(XVII) Chain (CS-COL17A1), which together enhance hair follicle stem cell (HFSC) activity. The research identifies the hsa-novel-238a-CASP9 axis as a crucial regulatory mechanism, suggesting it as a promising target for therapeutic interventions. The combined application of DPC-Exos and CS-COL17A1 significantly improves HFSC migration and proliferation, offering potential for innovative treatments for hair loss. However, the study's findings are primarily based on in vitro experiments, necessitating further validation in vivo.
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