Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study

November 2025 in “ Journal of Cosmetic Dermatology ”

Suparuj Lueangarun, Patrick Po‐Han Huang, Wan‐Yi Chou, Elina Theodorakopoulou, Daniela Lemes

exosome therapy hair repigmentation rose stem cell-derived exosomes androgenetic alopecia

Studysummary This study found that exosome-based therapy using rose stem cell-derived exosomes may safely induce hair repigmentation in individuals with gray hair, particularly for those with shorter durations of graying and androgenetic alopecia.

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This study explored the potential of exosome-based therapy to induce hair repigmentation in 10 patients with graying hair, primarily of Asian ethnicity and around 58.6 years old. Participants underwent an average of 4.6 treatment sessions, with methods like microneedling and jet-based transdermal delivery. Results indicated progressive repigmentation, with 60% of patients achieving moderate to marked improvement, and no adverse effects reported. The therapy may reactivate melanocyte stem cells, but the study's small sample size and lack of a control group limit its conclusions. Further research with larger samples is needed to validate these promising findings.

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This review highlights the potential of exosomes, particularly their microRNA components, as promising candidates for developing effective hair loss treatments by exploring their roles in hair follicle development and regeneration.

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