Platelet-Derived Extracellular Vesicles Promote Hair Follicle Growth Through Beta-Catenin Signaling Pathway

This study demonstrates that platelet-derived extracellular vesicles (PEVs) promote hair follicle growth by activating the β-catenin signaling pathway, offering a promising treatment for hair loss. PEVs were tested on dermal papilla cells and in a mouse model, showing enhanced proliferation and migration of these cells, and increased hair follicle growth. The study involved six mice per experimental group and found that PEVs contain growth factors like PDGF-BB and bFGF, which contribute to their effectiveness. PEVs were shown to accelerate the transition from the telogen to the anagen phase of hair growth, with significant effects observed at a concentration of 60 μg/mL. The findings suggest that PEVs could be a safe, effective, and cost-efficient alternative to current hair loss treatments, though further research is needed to assess their impact on specific conditions like androgenetic alopecia.