Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats

    Zhang Chun-hua, Le Fu, Shengli Li, Wu Sachula, Bao Hua, Lan Mu, Marco Antonini, Haizhou Sun
    This review discusses the critical role of microRNAs (miRNAs) in regulating hair follicle development and cycling in cashmere goats, which are prized for their fine fiber. It highlights the influence of key miRNAs, such as miR-31, miR-22, and miR-214, on hair follicle morphogenesis, regeneration, and fiber traits. Recent advances in single-cell RNA sequencing and spatial transcriptomics have provided new insights into cellular heterogeneity and lineage specification. Integrative multi-omics approaches reveal complex regulatory networks involving miRNAs, while AI-driven analytics enhance biomarker discovery and therapeutic target identification. These findings inform breeding strategies to improve cashmere fiber quality and offer minimally invasive diagnostic tools for hair disorders. Future directions include improved miRNA delivery methods and AI-powered multi-omics approaches to advance hair follicle biology understanding and practical applications in medicine and agriculture.
    Discuss this study in the Community →

    Research cited in this study

    100 / 100 results

    Related Community Posts Join

    6 / 9 results

    Related Research

    7 / 7 results