Stem Cell-Based Approaches for Alopecia: A Narrative Review of Current and Emerging Treatment Strategies

    June 2026 in “ Cell Transplantation ”
    Pitsunan Paphawannasri, Tulyapruek Tawonsawatruk, Jitrada Phetfong, Aungkura Supokawej
    Studysummary This review highlights the potential of stem cell-based therapies, including hair follicle, mesenchymal, and induced pluripotent stem cells, as promising future treatments for alopecia, noting their regenerative and immunomodulatory capabilities as well as ongoing studies evaluating their effectiveness in overcoming current therapy limitations.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 96

    1. Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine ACS Biomaterials Science & Engineering · 2026
    2. Advanced Medical Treatments for Hair Loss Cell Transplantation · 2025
    3. Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources Clinical Cosmetic and Investigational Dermatology · 2025
    4. Evaluating Current and Emerging JAK Inhibitors for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    5. Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment Drug Design Development and Therapy · 2025
    6. Therapeutic Potential of Stem Cell-Derived Exosomes in Hair Regeneration: A Systematic Review World Journal of Stem Cells · 2025
    7. Causes and Therapeutic Limitations of Clinical Alopecia and the Advent of Human Pluripotent Stem Cell Follicular Transplantation Stem Cell Research & Therapy · 2025
    8. Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies Stem Cell Research & Therapy · 2025
    9. Local Corticosteroids for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    10. Epidemiological Landscape of Androgenetic Alopecia in the US: An All of Us Cross-Sectional Study PLoS ONE · 2025
    11. Bulge-Derived Epithelial Cells Isolated From Human Hair Follicles Using Enzymatic Digestion Or Explants Result In Comparable Tissue-Engineered Skin International Journal of Molecular Sciences · 2025
    12. Application of Platelet-Rich Plasma Lysate Combined with Hyaluronic Acid Microneedles for the Treatment of Alopecia Drug Delivery and Translational Research · 2025
    13. Functional Regeneration Strategies of Hair Follicles: Advances and Challenges Stem Cell Research & Therapy · 2025
    14. Applications and Efficacy of Minoxidil in Dermatology Skin Health and Disease · 2024
    15. Hair Follicle Stem Cells and the Collapse of Self-Tolerance in Alopecia: The Interplay of Barrier Function, the Microbiome, and Immunity EMBO Molecular Medicine · 2024
    16. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    17. Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells Stem Cell Research & Therapy · 2024
    18. Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model International Journal of Molecular Sciences · 2024
    19. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    20. Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata JAMA Dermatology · 2024
    21. Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway Journal of Nanobiotechnology · 2024
    22. An Induced Pluripotent Stem Cell-Based Approach for Hair Follicle Development and Regeneration Regenerative Therapy · 2024
    23. Promotion of Hair Growth by a Conditioned Medium from Human Umbilical Cord Mesenchymal Stem Cells Cultivated in a 3D Scaffold of Gelatin Sponge European journal of medical research · 2024
    24. Evaluation of the Effects of Adding an Adipose Tissue-Derived Stromal Vascular Fraction to Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: A Randomized Clinical Trial Skin research and technology · 2024
    25. The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration Biomedicines · 2024
    26. Efficacy and Safety of Topical Corticosteroid Treatment Under Occlusion for Severe Alopecia Areata in Children: A Single-Center Retrospective Analysis Clinical and experimental dermatology · 2024
    27. Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles World Journal of Stem Cells · 2024
    28. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    29. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    30. Is Thyroid Dysfunction a Common Cause of Telogen Effluvium? A Retrospective Study Medicine · 2024
    31. Design and Proof-of-Concept of Single Robotic Hair Transplant Mechanisms for Both Harvest and Implant of Hair Grafts Computational and Structural Biotechnology Journal · 2023
    32. Clinical Benefits of Baricitinib Therapy for Severe Alopecia Areata Dermatology and Therapy · 2023
    33. The Menopausal Transition: Is the Hair Follicle Going Through Menopause? Biomedicines · 2023
    34. Inflammatory Loops in the Epithelial-Immune Microenvironment of the Skin and Skin Appendages in Chronic Inflammatory Diseases Frontiers in immunology · 2023
    35. Trajectory of Human Induced Pluripotent Stem Cells Derived Neural Progenitor Cells Differentiation into Dermal Papilla-Like Cells and Their Characteristics Scientific reports · 2023
    36. Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial Stem Cell Research & Therapy · 2023
    37. Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review Dermatology and Therapy · 2023
    38. Platelet Rich Plasma Combination Therapies for Treatment of Androgenetic Alopecia: A Systematic Review Journal of Cutaneous and Aesthetic Surgery · 2023
    39. A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle Plastic and Reconstructive Surgery · 2023
    40. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    41. Androgenetic Alopecia: Therapy Update Drugs · 2023
    42. Human Stem Cell Use in Androgenetic Alopecia: A Systematic Review Cells · 2023
    43. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    44. Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis Burns and trauma · 2023
    45. Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review Skin appendage disorders · 2023
    46. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    47. How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes · 2022
    48. Generation of Human-Induced Pluripotent Stem Cell-Derived Adherent 3-Dimensional Skin Hair-Follicle Organoids Organoid · 2022
    49. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    50. Topical Finasteride for Male and Female Pattern Hair Loss: Is It a Safe and Effective Alternative? Journal of Cosmetic Dermatology · 2022
    51. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022
    52. Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022
    53. Insulin Resistance and Elevated Androgen Levels: A Major Cause of Polycystic Ovary Syndrome Frontiers in Endocrinology · 2021
    54. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    55. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    56. MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020
    57. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    58. A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia Expert Opinion on Biological Therapy · 2020
    59. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    60. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    61. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Drug Design Development and Therapy · 2020
    62. Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature Skin appendage disorders · 2020
    63. Efficacy of Platelet-Rich Plasma and Concentrated Growth Factor in Treating Androgenetic Alopecia: A Retrospective Study Annals of maxillofacial surgery · 2020
    64. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    65. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    66. Polycystic Ovarian Syndrome: Correlation Between Hyperandrogenism, Insulin Resistance, and Obesity Clinica Chimica Acta · 2019
    67. Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead Journal of Maxillofacial and Oral Surgery · 2019
    68. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    69. Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation Cell reports · 2019
    70. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    71. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    72. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    73. Introducing Platelet-Rich Stroma: Platelet-Rich Plasma and Stromal Vascular Fraction Combined for the Treatment of Androgenetic Alopecia Aesthetic Surgery Journal · 2018
    74. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    75. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    76. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    77. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    78. Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature Stem cell investigation · 2017
    79. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    80. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    81. The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds) Stem Cells International · 2017
    82. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model Annals of Dermatology · 2016
    83. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    84. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    85. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    86. Efficacy of Finasteride for Treating Patients with Androgenetic Alopecia Who Are Pileous in Other Areas: A Pilot Study in Japan Indian Journal of Dermatology · 2014
    87. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    88. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    89. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    90. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    91. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    92. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    93. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    94. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    95. Finasteride Drugs · 1999
    96. Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells Development · 1996