Hair Follicle Stem Cells and the Collapse of Self-Tolerance in Alopecia: The Interplay of Barrier Function, the Microbiome, and Immunity

    November 2024 in “ EMBO Molecular Medicine ”
    Joseph S. Durgin, Sunny Y. Wong
    Studysummary This study used a mouse model to enhance understanding of alopecia pathogenesis and suggested a therapeutic strategy for managing inflammation in EGFR-inhibitor therapy-induced folliculitis and cicatricial alopecia.
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    Research cited in this study 7

    1. JAK-STAT1 as Therapeutic Target for EGFR Deficiency-Associated Inflammation and Scarring Alopecia EMBO Molecular Medicine · 2024
    2. Hair Follicles Modulate Skin Barrier Function Cell Reports · 2024
    3. Regulatory T Cells in Skin Mediate Immune Privilege of the Hair Follicle Stem Cell Niche Science Immunology · 2024
    4. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    5. Hair Eruption Initiates and Commensal Skin Microbiota Aggravate Adverse Events of Anti-EGFR Therapy Science Translational Medicine · 2019
    6. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018
    7. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013