Epidermal Growth Factor Receptor Protects From Immune Privilege Collapse and Scarring Hair Follicle Destruction
epidermal growth factor receptor EGFR immune privilege collapse scarring alopecia EGFR-inhibitor alopecia chronic inflammation stem cells apoptosis fibrotic scarring RNA sequencing antigen presentation machinery inflammatory pathways cicatricial alopecia Folliculitis decalvans scarring hair loss hair loss immune system collapse cell death immune system activation
Studysummary This study reported that in mouse models, deletion of EGFR resulted in stem cell hyper-proliferation followed by apoptosis, leading to scarring alopecia, and implicated EGFR's role in maintaining hair follicle quiescence and immune privilege during inflammation.
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