Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine

This study explores the use of human induced pluripotent stem cells (hiPSCs) to create hair follicle organoids (HFOs) for hair regenerative medicine. Researchers successfully differentiated hiPSCs into ectodermal precursor cells and used them to generate human/mouse chimeric HFOs, which showed hair follicle sprouting both in vitro and in vivo. The study highlights the potential of using collagen I as a microenvironment for HFO induction, as an alternative to Matrigel, which is unsuitable for human treatment. Although further work is needed to induce human mesenchymal layer cells from hiPSCs for fully human HFOs, the findings demonstrate the promise of hiPSC-derived ectodermal precursor cells in hair regeneration.