Role and Mechanisms of Phytochemicals in Hair Growth and Health

    January 2023 in “Pharmaceuticals
    Periyanaina Kesika, Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Muruganantham Bharathi, Chaiyavat Chaiyasut
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    TLDR Natural products and phytochemicals may help with hair regrowth, but more research is needed.
    The review "Role and Mechanisms of Phytochemicals in Hair Growth and Health" discusses the various factors affecting hair health and loss, including genetics, disease, lifestyle, and exposure to certain substances. It highlights the potential of phytochemicals, such as epigallocatechin gallate (EGCG), caffeine, capsaicin, and others, in developing treatments for hair problems. The paper also discusses the effectiveness of various treatments for hair loss, including minoxidil, finasteride, dutasteride, and cell therapy. It emphasizes the potential of natural products and phytochemicals in promoting hair regrowth, but concludes that further detailed studies are needed. The document also presents various studies showing the hair growth-promoting properties of different substances, including castor oil, Eclipta alba extract, and Carthamus tinctorius L. florets-loaded nanostructured lipid carrier (CTNLC). It also discusses the mechanisms through which phytochemicals promote hair growth and prevent hair loss, including interaction with the TGF-β pathway, β-catenin, JAK/STAT3 pathway, ERK signaling pathway, and 5α-reductase inhibitory property.
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