Hair Longevity—Evidence for a Multifactorial Holistic Approach to Managing Hair Aging Changes

    March 2025 in “ Journal of Clinical Medicine ”
    Gillian Elizabeth Westgate, Daniela Grohmann, Manuel Sáez Moya
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    Research cited in this study 108

    1. Exosomes for Aesthetic Dermatology: A Comprehensive Literature Review and Update Journal of Cosmetic Dermatology · 2025
    2. A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair Journal of Cosmetic Dermatology · 2025
    3. New Plant Extracts Exert Complementary Anti-Hair Loss Properties in Human In Vitro and Ex Vivo Models Journal of Cosmetic Dermatology · 2024
    4. Micronutrients And Androgenetic Alopecia: A Systematic Review Molecular Nutrition & Food Research · 2024
    5. Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression World Journal of Psychiatry · 2024
    6. Red And Green LED Light Therapy: A Comparative Study In Androgenetic Alopecia Photodermatology Photoimmunology & Photomedicine · 2024
    7. The Effects of Oral Supplementation of Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Clinical Study in Healthy Women Journal of Cosmetic Dermatology · 2024
    8. Vitamin D Deficiency in Non-Scarring and Scarring Alopecias: A Systematic Review and Meta-Analysis Frontiers in Nutrition · 2024
    9. Bleached Hair as a Standard Template to Evaluate the Performance of Commercial Hair Repair Products Cosmetics · 2024
    10. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    11. A Comprehensive Investigation of Biochemical Status in Patients with Telogen Effluvium: Analysis of Hb, Ferritin, Vitamin B12, Vitamin D, Thyroid Function Tests, Zinc, Copper, Biotin, and Selenium Levels Journal of Cosmetic Dermatology · 2024
    12. Hair Follicle Sulfotransferase Activity and Effectiveness of Oral Minoxidil in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2024
    13. Activation of the Integrated Stress Response in Human Hair Follicles PLoS ONE · 2024
    14. Physical Treatments and Therapies for Androgenetic Alopecia 2024
    15. Enhanced Insights Into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies Dermatology and Therapy · 2024
    16. Anti-Hair Loss Effect of a Shampoo Containing Caffeine and Adenosine Journal of cosmetic dermatology · 2024
    17. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    18. Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege International Journal of Cosmetic Science · 2024
    19. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    20. Spatial Distribution and Functional Impact of Human Scalp Hair Follicle Microbiota Journal of Investigative Dermatology · 2023
    21. Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study Clinical, Cosmetic and Investigational Dermatology · 2023
    22. The Gut and Skin Microbiome in Alopecia: Associations and Interventions PubMed · 2023
    23. Clinical Study on the Efficacy and Tolerability of an Oral Supplement Based on Arginine, L-Cystine, Zinc and B6 Vitamin (Cystiphane) in Patients With Telogen Effluvium Italian journal of dermatology and venereology · 2023
    24. Efficacy and Tolerability of an Oral Supplement Containing Amino Acids, Iron, Selenium, and Marine Hydrolyzed Collagen in Subjects With Hair Loss: A Prospective, Randomized, 3-Month, Controlled, Assessor-Blinded Study Skin Research and Technology · 2023
    25. Shedding Low Yield Testing for Telogen Effluvium: A Cross-Sectional Study of Laboratory Results from Newly Diagnosed Patients Journal of The American Academy of Dermatology · 2023
    26. Male-Pattern Hair Loss: Comprehensive Identification of the Associated Genes as a Basis for Understanding Pathophysiology Medizinische Genetik · 2023
    27. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    28. Hair Aging and Hair Disorders in Elderly Patients International Journal of Trichology · 2022
    29. Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype Nutrients · 2022
    30. Sex Differences in Clinical Trials of ALRV5XR Treatment of Androgenetic Alopecia and Telogen Effluvium Frontiers in Medicine · 2022
    31. Skin, Hair, and Beyond: The Impact of Menopause Climacteric · 2022
    32. Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells Molecules · 2022
    33. Oral Minoxidil Use in Androgenetic Alopecia and Telogen Effluvium Archives of Dermatological Research · 2022
    34. Targeted Nutritional Supplementation for Telogen Effluvium: Multicenter Study on Efficacy of a Hydrolyzed Collagen, Vitamin, and Mineral-Based Induction and Maintenance Treatment International Journal of Trichology · 2022
    35. Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin, and MIP-1α in the Adipose-Derived Stem Cell Secretome in Androgenetic Alopecia Experimental Dermatology · 2022
    36. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    37. Advances in Hair Growth Faculty reviews · 2022
    38. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    39. Prevalence of Low Serum Vitamin D Levels in Patients Presenting With Androgenetic Alopecia: A Review Cureus · 2021
    40. Scarring Alopecias: Pathology and an Update on Digital Developments Biomedicines · 2021
    41. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    42. Injectable Platelet Rich Fibrin Facilitates Hair Follicle Regeneration by Promoting Human Dermal Papilla Cell Proliferation, Migration, and Trichogenic Inductivity Experimental Cell Research · 2021
    43. Scalp Application of Antioxidants Improves Scalp Condition and Reduces Hair Shedding in a 24-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial International Journal of Cosmetic Science · 2021
    44. Measuring Patient Quality of Life Following Treatment for Alopecia Patient Preference and Adherence · 2021
    45. Safety and Efficacy of ALRV5XR in Women with Androgenetic Alopecia or Telogen Effluvium: A Randomised, Double-Blinded, Placebo-Controlled Clinical Trial EClinicalMedicine · 2021
    46. Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial Journal of Cosmetic Dermatology · 2021
    47. Efficacy of Oral Vitamin D3 Therapy in Patients Suffering from Diffuse Hair Loss (Telogen Effluvium) Journal of Nutritional Science and Vitaminology · 2021
    48. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020
    49. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    50. Biotin Deficiency in Telogen Effluvium: Fact or Fiction? PubMed · 2020
    51. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    52. Placebo-Controlled Dose-Effect Studies with Topical Minoxidil 2% or 5% in Male-Patterned Hair Loss Treated with Oral Finasteride Employing an Analytical and Exhaustive Study Protocol Skin Research and Technology · 2020
    53. Serum Ferritin and Vitamin D Levels Should Be Evaluated in Patients With Diffuse Hair Loss Prior to Treatment Postepy Dermatologii I Alergologii · 2020
    54. Advances in Stem Cell-Based Therapy for Hair Loss PubMed · 2020
    55. Short Communication: Clinical Evaluation of Pea Sprout Extract in the Treatment of Hair Loss Phytotherapy Research · 2019
    56. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    57. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    58. Can Plant-Derived Phytochemicals Provide Symptom Relief for Hair Loss? A Critical Review International Journal of Cosmetic Science · 2019
    59. Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway BMC Complementary and Alternative Medicine · 2019
    60. Microbiome in the Hair Follicle of Androgenetic Alopecia Patients PLOS ONE · 2019
    61. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    62. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    63. A Liposome-Based Formulation Containing Equol, Dihomo-γ-Linolenic Acid, and Propionyl-L-Carnitine to Prevent and Treat Hair Loss: A Prospective Investigation Dermatologic Therapy · 2018
    64. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    65. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    66. A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair PubMed · 2018
    67. The Effectiveness of Adding Low-Level Light Therapy to Minoxidil 5% Solution in the Treatment of Patients with Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    68. A Proprietary Herbal Extract Against Hair Loss in Androgenetic Alopecia and Telogen Effluvium: A Placebo-Controlled, Single-Blind, Clinical-Instrumental Study Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2018
    69. The Role of Vitamin D in Non-Scarring Alopecia International Journal of Molecular Sciences · 2017
    70. A Spermidine-Based Nutritional Supplement Prolongs the Anagen Phase of Hair Follicles in Humans: A Randomized, Placebo-Controlled, Double-Blind Study Dermatology practical & conceptual · 2017
    71. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    72. Efficacy and Safety of a Food Supplement Containing L-Cystine, Serenoa Repens Extract, and Biotin for Hair Loss in Healthy Males and Females: A Prospective, Randomized, Double-Blinded, Controlled Clinical Trial Journal of cosmetology & trichology · 2017
    73. Vitamin and Mineral Deficiencies in Patients With Telogen Effluvium: A Retrospective Cross-Sectional Study PubMed · 2016
    74. Stress And The Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption PubMed · 2016
    75. Hormones and Clocks: Do They Disrupt the Locks? Fluctuating Estrogen Levels During Menopausal Transition May Influence Clock Genes and Trigger Chronic Telogen Effluvium Dermatology Online Journal · 2016
    76. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    77. The Topical Penta-Peptide Gly-Pro-Ile-Gly-Ser Increases the Proportion of Thick Hair in Japanese Men with Androgenetic Alopecia Journal of Cosmetic Dermatology · 2016
    78. Hair Regrowth in Male and Female Pattern Hair Loss Does Not Involve the Conversion of Vellus Hair to Terminal Hair Experimental Dermatology · 2016
    79. Non-Invasive Method Distinguishes Chronic Telogen Effluvium From Mild Female Pattern Hair Loss: Clinicopathological Correlation International Journal of Dermatology · 2015
    80. Gender Differences in Scalp Hair Growth Rates Are Maintained but Reduced in Pattern Hair Loss Compared to Controls Skin Research and Technology · 2015
    81. Female Pattern Alopecia and Telogen Effluvium: Figuring Out Diffuse Alopecia Seminars in Cutaneous Medicine and Surgery · 2015
    82. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    83. Postpartum Telogen Effluvium Journal of the European Academy of Dermatology and Venereology · 2015
    84. Chronic Telogen Effluvium and Female Pattern Hair Loss Are Separate and Distinct Forms of Alopecia: A Histomorphometric and Immunohistochemical Analysis Clinical and Experimental Dermatology · 2014
    85. Evidence for a Polygenic Contribution to Androgenetic Alopecia British Journal of Dermatology · 2013
    86. A Descriptive Study of Alopecia Patterns and Their Relation to Thyroid Dysfunction International Journal of Trichology · 2013
    87. Oral Zinc Therapy for Zinc Deficiency-Related Telogen Effluvium Dermatologic Therapy · 2012
    88. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    89. How Real Is Senescent Alopecia? A Histopathologic Approach Clinics in Dermatology · 2010
    90. Iron Deficiency in Female Pattern Hair Loss, Chronic Telogen Effluvium, and Control Groups Journal of The American Academy of Dermatology · 2010
    91. Iron Status in Diffuse Telogen Hair Loss Among Women PubMed · 2009
    92. Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial Journal of Dermatology · 2008
    93. Low Iron Stores: A Risk Factor for Excessive Hair Loss in Non-Menopausal Women PubMed · 2008
    94. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    95. Healthy Hair: What Is It? ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2007
    96. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    97. Iron and Hair Loss in Women: What Is Deficiency? This Is the Real Question! Journal of The American Academy of Dermatology · 2007
    98. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    99. Aging of Hair Journal of Cosmetic Dermatology · 2005
    100. Free Internal Lipids in Hair From Pre- and Post-Menopausal Women International Journal of Cosmetic Science · 2005
    101. Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes Associated with Aging Micron · 2003
    102. Is There Really No Clear Association Between Low Serum Ferritin and Chronic Diffuse Telogen Hair Loss? British Journal of Dermatology · 2003
    103. Validation and Clinical Relevance of a Novel Scalp Coverage Scoring Method Skin Research and Technology · 2003
    104. There Is No Clear Association Between Low Serum Ferritin And Chronic Diffuse Telogen Hair Loss British Journal of Dermatology · 2002
    105. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002
    106. Hair Loss and Hirsutism in the Elderly Clinics in Geriatric Medicine · 2002
    107. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    108. Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Journal of Investigative Dermatology · 1993

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