The Topical Penta-Peptide Gly-Pro-Ile-Gly-Ser Increases the Proportion of Thick Hair in Japanese Men with Androgenetic Alopecia

March 2016 in “ Journal of Cosmetic Dermatology ”

Tokuro Iwabuchi, Shunsuke Takeda, Haruyo Yamanishi, Ritsuro Ideta, Ritsuko Ehama, Akinori Tsuruda, Hideaki Shibata, Tomoko Ito, Nobuyuki Komatsu, Keiko Terai, Syuichi Oka

androgenetic alopecia penta-peptide Gly-Pro-Ile-Gly-Ser hair keratinocytes hair shaft elongation AGA GPIGS

TLDR GPIGS peptide increases thick hair growth in balding Japanese men.

A study conducted on Japanese men with androgenetic alopecia (AGA) investigated the effectiveness of a topical penta-peptide Gly-Pro-Ile-Gly-Ser (GPIGS) in promoting hair growth. The peptide was found to stimulate the proliferation of hair keratinocytes and hair shaft elongation in vitro. In a clinical trial, the penta-peptide was found to increase the proportion of thick hair in Japanese men with AGA, and improved the appearance of baldness. No adverse effects were noted during the study, and the authors suggest that the penta-peptide may be a potential treatment for AGA.

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research The Topical Penta-Peptide Gly-Pro-Ile-Gly-Ser Increases the Proportion of Thick Hair in Japanese Men with Androgenetic Alopecia

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The Topical Penta-Peptide Gly-Pro-Ile-Gly-Ser Increases the Proportion of Thick Hair in Japanese Men with Androgenetic Alopecia

Research cited in this study

research Improvement of Androgenetic Alopecia with Topical Sophora Flavescens Aiton Extract, and Identification of the Two Active Compounds in the Extract That Stimulate Proliferation of Human Hair Keratinocytes

research Contribution of Hair Density and Hair Diameter to the Appearance and Progression of Androgenetic Alopecia in Japanese Men

research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

research Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

research A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice

research Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

research Effects of Cepharanthine and Minoxidil on Proliferation, Differentiation, and Keratinization of Cultured Cells from the Murine Hair Apparatus

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

research Hypertrichosis Due to Minoxidil

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