A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice

    January 2005 in “ Biological & Pharmaceutical Bulletin ”
    Akinori Tsuruda, Yasuhiro Kawano, Taira Maekawa, Syuichi Oka
    Studysummary This study reports that the peptide GPIGS, found in Bacillus sp. M18 conditioned medium, may promote hair growth through the PI-3K/Akt pathway and accelerate hair regrowth in mice.
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    Research cited in this study 18

    1. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    2. The Potential Role of Minoxidil in the Hair Transplantation Setting Dermatologic Surgery · 2002
    3. The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent PTR. Phytotherapy research/Phytotherapy research · 2001
    4. KF19418, A New Compound for Hair Growth Promotion in Vitro and in Vivo Mouse Models Journal of Dermatological Science · 2001
    5. Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent Phytomedicine · 2000
    6. A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression The FASEB Journal · 2000
    7. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    8. Androgenetic Alopecia: In Vivo Models Experimental and Molecular Pathology · 1999
    9. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    10. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    11. Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice Journal of Dermatological Science · 1998
    12. Organ Culture of Human Hair Follicles in Serum-Free Medium Archives of Dermatological Research · 1993
    13. Effects of Cepharanthine and Minoxidil on Proliferation, Differentiation, and Keratinization of Cultured Cells from the Murine Hair Apparatus Archives of Dermatological Research · 1992
    14. Animal Models of Androgen-Dependent Disorders of the Pilosebaceous Apparatus Archives of dermatological research · 1989
    15. Topical Minoxidil in Early Male Pattern Baldness Journal of The American Academy of Dermatology · 1985
    16. Topical Minoxidil Therapy in Hereditary Androgenetic Alopecia Archives of Dermatology · 1985
    17. Alopecia Areata Treated With Topical Minoxidil Archives of Dermatology · 1984
    18. Topical Minoxidil in the Treatment of Alopecia Areata BMJ · 1983