Spatial Distribution and Functional Impact of Human Scalp Hair Follicle Microbiota

December 2023 in “ Journal of Investigative Dermatology ”

Marta B. Lousada, Janin Edelkamp, Tim Lachnit, Markus Fehrholz, Irena Pastar, Francisco Jiménez, Hanieh Erdmann, Thomas C. G. Bosch, Ralf Paus

hair follicles Cutibacterium acnes Malassezia restricta butyrate catagen autophagy HF mesenchyme

TLDR Scalp hair follicle microbes affect hair health and could be used for treatments.

This study examines the microbiota of human scalp hair follicles (HFs), focusing on their spatial distribution and functional impact. Using advanced techniques, the research identifies Cutibacterium acnes and Malassezia restricta as predominant HF colonizers, particularly in the HF mesenchyme. The study highlights the role of microbial products like butyrate in modulating HF functions, such as delaying catagen and promoting autophagy. The findings suggest that HF microbiota significantly influence HF physiology and could be targeted for therapeutic purposes. The study involved 10 male donors, providing a detailed analysis of HF-specific microbiota.

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