Hormones and Clocks: Do They Disrupt the Locks? Fluctuating Estrogen Levels During Menopausal Transition May Influence Clock Genes and Trigger Chronic Telogen Effluvium

    May 2016 in “ Dermatology Online Journal
    Paradi Mirmirani
    Image of study
    TLDR Changing estrogen levels during menopause might affect genes related to body rhythms and cause increased hair loss.
    The 2016 paper "Hormones and clocks: do they disrupt the locks? Fluctuating estrogen levels during menopausal transition may influence clock genes and trigger chronic telogen effluvium" proposed a hypothesis that chronic telogen effluvium (CTE), a condition of increased, diffuse scalp hair shedding mostly in middle-aged women, may be triggered by hormonal fluctuations and alterations in circadian control genes. Despite being described almost 20 years prior, the underlying cause of CTE was not identified at the time of this paper. The authors suggested that the combination of research in hair biology and the emerging field of chronobiology could lead to significant breakthroughs in understanding CTE.
    Discuss this study in the Community →

    Research cited in this study

    26 / 26 results

    Related Community Posts Join

    6 / 323 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Could Finasteride theoretically induce chronic telogen effluvium?

      in Finasteride/Dutasteride  7 upvotes 6 months ago
      A user experienced continuous hair shedding for 13 months after starting finasteride, suspecting it might cause chronic telogen effluvium, and considered switching to dutasteride or stopping medication. Other users suggested that finasteride doesn't cause hair loss, recommending dutasteride for more aggressive hair loss, while some advised against stopping medication.

      community 9 years of hair loss process and 27 months of treatment. What's going on?

      in Finasteride/Dutasteride  40 upvotes 2 months ago
      The user experienced hair loss diagnosed as chronic Telogen Effluvium and male pattern baldness, treated with finasteride and minoxidil, later switching to dutasteride due to side effects but with limited success. The user plans to return to finasteride due to side effects from dutasteride, while others suggest maintaining consistent treatment and considering additional options like oral minoxidil and lifestyle changes.

      community Is 2years+ telogen effluvium possible?

      in Finasteride/Dutasteride  2 upvotes 1 year ago
      The user has been losing hair for over two years despite taking dutasteride and RU58841, even increasing dutasteride to 2.5mg. They are questioning if their hair loss could be due to telogen effluvium instead.

      community 25M Exploring Causes of Hair Loss: TE, Alopecia, or AGA?

      in General  226 upvotes 5 days ago
      The user is experiencing hair loss with possible causes including chronic telogen effluvium, diffuse alopecia areata, and androgenic alopecia. They have tried treatments like Nizoral shampoo, minoxidil, and finasteride, and are considering a biopsy for further clarity.

    Related Research

    8 / 8 results