Scarring Alopecias: Pathology and an Update on Digital Developments

    November 2021 in “ Biomedicines
    Donna M. Cummins, Iskander H. Chaudhry, Matthew Harries
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    TLDR New digital tools are improving the diagnosis and understanding of irreversible hair loss conditions.
    The document "Scarring Alopecias: Pathology and an Update on Digital Developments" discusses the challenges in diagnosing primary cicatricial alopecias (PCA), irreversible hair loss conditions due to the destruction and fibrosis of hair follicles. It emphasizes the importance of communication between the clinician, laboratory, and histopathologist, and the use of special stains in diagnosis. The document also discusses the North American Hair Research Society's classification of PCA, the speculated pathogenesis of cicatricial alopecia, and the histopathology of PCAs. It provides details on various types of scarring alopecias, including Discoid lupus erythematosus (DLE), Central Centrifugal Cicatricial Alopecia (CCCA), Pseudopelade of Brocq (PsB), and Folliculitis decalvans. The document also highlights the potential of digital pathology, specifically Whole Slide Imaging (WSI), in improving specialist hair loss services and the potential of artificial intelligence in advancing digital technologies in the field of hair loss.
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      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Research/Science  94 upvotes 8 months ago
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      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  56 upvotes 7 months ago
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