Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia

    December 2018 in “ The American Journal of Dermatopathology ”
    Timothy L. Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
    Image of study
    TLDR Early shedding of the inner root sheath in noninflamed hair follicles is a relatively specific sign of Central Centrifugal Cicatricial Alopecia.
    The study "Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia" conducted a retrospective analysis on 501 cases of alopecia. The researchers found that premature desquamation of the inner root sheath (PDIRS) was identified in all alopecia subtypes evaluated. However, PDIRS in noninflamed follicles was found in 73% (81/111) of Central Centrifugal Cicatricial Alopecia (CCCA) cases, making it a relatively specific marker for this condition. The presence of PDIRS in at least one noninflamed hair follicle correlated with a diagnosis of CCCA with a sensitivity of 73% and a specificity of 98% (P-value <0.0001).
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 115 results

      community Has any premature balding guys actually saved and maintained their hair?

      in Chat  17 upvotes 1 month ago
      A user discusses their struggle with aggressive hair loss starting at a young age and their use of various treatments, including topical finasteride, minoxidil, dutasteride, and RU58841, without significant success. Other users share their experiences and suggest trying oral finasteride or dutasteride, topical spironolactone, and maintaining a vitamin regimen, while noting potential side effects like gynecomastia.
      [object Object]

      community SAFFLOWER OIL good alternative for Minoxidil?

      in Treatment  1 upvotes 5 years ago
      Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

      community Why is it barely impossible to find balding South Korean men

      in Research/Science  249 upvotes 1 year ago
      The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.

    Related Research

    2 / 2 results