Studysummary This study found that rhIL-15 promotes human hair follicle growth and regrowth in experimental settings and may have therapeutic potential for alopecia areata by restoring immune privilege guardianship.
Read the full study on linkinghub.elsevier.com →
Research cited in this study 62
- Long-Term Efficacy and Safety of Baricitinib in Patients With Severe Alopecia Areata: 104-Week Results From BRAVE-AA1 and BRAVE-AA2 Journal of the European Academy of Dermatology and Venereology · 2024
- Comparative Efficacy of Oral Janus Kinase Inhibitors and Biologics in Adult Alopecia Areata: A Systematic Review and Bayesian Network Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2024
- Effectiveness and Predictive Factors of Response to Tofacitinib Therapy in 125 Patients with Alopecia Areata: A Single-Centre Real-World Retrospective Study Acta dermato-venereologica · 2023
- Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023
- IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles Journal of Investigative Dermatology · 2023
- Successful Treatment of Alopecia Universalis With Abrocitinib: A Case Report Journal of Dermatological Treatment · 2023
- Janus Kinase Inhibitors for Alopecia Areata Journal of the American Academy of Dermatology · 2023
- Functional Interrogation of Lymphocyte Subsets in Alopecia Areata Using Single-Cell RNA Sequencing Proceedings of the National Academy of Sciences · 2023
- Beyond Health-Related Quality of Life: Initial Psychometric Validation of a New Scale for Addressing the Gap in Assessing the Full Range of Alopecia Areata Psychosocial Burden British Journal of Dermatology · 2023
- MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation EMBO reports · 2023
- Factors Predicting Response to Oral Methylprednisolone Tapering Treatment in Alopecia Areata: A Retrospective Study Journal of the American Academy of Dermatology · 2023
- Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
- Interleukin-15 and Tumor Necrosis Factor-Alpha in Iraqi Patients with Alopecia Areata Dermatology Research and Practice · 2023
- Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
- Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway Indian Dermatology Online Journal · 2023
- Topical SCD-153, A 4-Methyl Itaconate Prodrug, For The Treatment Of Alopecia Areata PNAS nexus · 2022
- An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
- The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies Frontiers in pharmacology · 2022
- The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care British Journal of Dermatology · 2022
- Alopecia Areata: Current Understanding and Management Journal der Deutschen Dermatologischen Gesellschaft · 2022
- Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
- Evaluation of the Level of Serum Interleukins (IL-2, IL-4, IL-15, and IL-17) and Its Relationship with Disease Severity in Patients with Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2021
- The Epidemiology of Alopecia Areata: A Population-Based Cohort Study in UK Primary Care British Journal of Dermatology · 2021
- Udp-GlcNAc-1-Phosphotransferase Is A Clinically Important Regulator Of Human And Mouse Hair Pigmentation Journal of Investigative Dermatology · 2021
- Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
- Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review Dermatology and Therapy · 2021
- Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance Journal of Investigative Dermatology · 2021
- Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing Its Impact on T Regulatory Cell and NK Cell Populations The journal of investigative dermatology/Journal of investigative dermatology · 2020
- The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
- Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
- Serum Level of Interleukin-15 in Active Alopecia Areata Patients and Its Relation to Age, Sex, and Disease Severity Advances in Dermatology and Allergology · 2020
- Frontiers in Alopecia Areata Pathobiology Research The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology · 2019
- Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
- The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019
- JAK Inhibitors and Alopecia Areata Lancet · 2019
- Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
- High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
- Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
- Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
- iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
- Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
- An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
- Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings · 2017
- Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
- Alopecia Areata: A Comprehensive Review of Pathogenesis and Management Clinical Reviews in Allergy & Immunology · 2017
- Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
- Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
- Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
- Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
- Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
- The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
- The Peripheral Clock Regulates Human Pigmentation The journal of investigative dermatology/Journal of investigative dermatology · 2014
- Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
- A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013
- Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
- Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
- Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
- Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
- Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
- Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
- Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
- Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005