Effectiveness and Predictive Factors of Response to Tofacitinib Therapy in 125 Patients with Alopecia Areata: A Single-Centre Real-World Retrospective Study

    December 2023 in “ Acta dermato-venereologica ”
    Jundong Huang, Qian Pei, Yan Tang … Wei Shi
    Studysummary This retrospective cohort study reported that oral tofacitinib was effective in treating alopecia areata, with 83.2% of patients showing improvement and 16.0% achieving complete remission. Earlier intervention and previous hair regrowth were linked to better outcomes, and no severe adverse events were observed.
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    Research cited in this study 20

    1. Real-World Treatment Patterns Among Patients With Alopecia Areata in the USA: A Retrospective Claims Analysis Acta dermato-venereologica · 2023
    2. Alopecia Areata: Current Treatments and New Directions American Journal of Clinical Dermatology · 2023
    3. Janus Kinase Inhibitors for Alopecia Areata Journal of the American Academy of Dermatology · 2023
    4. Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population JAMA Dermatology · 2023
    5. Alopecia Areata: Case Report and Review of Pathophysiology and Treatment with JAK Inhibitors Journal of autoimmunity · 2022
    6. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    7. The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies Frontiers in pharmacology · 2022
    8. Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study Frontiers in Medicine · 2022
    9. Treatments for Alopecia Areata: A Systematic Review and Network Meta-Analysis Dermatologic therapy · 2021
    10. Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing Its Impact on T Regulatory Cell and NK Cell Populations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2020
    11. Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2019
    12. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    13. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    14. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    15. Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction Archives of Dermatological Research · 2017
    16. Management of Alopecia Areata: Updates and Algorithmic Approach Journal of dermatology · 2017
    17. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    18. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    19. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
    20. Interleukin-10-Deficient Mice Are Less Susceptible to the Induction of Alopecia Areata Journal of Investigative Dermatology · 2002

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    2. Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study Frontiers in Medicine · 2022
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