The Future Of Alopecia Treatment: Plant Extracts, Nanocarriers, And 3D Bioprinting In Focus

    April 2025 in “ Pharmaceutics ”
    Rana E. Elnady, Manar S. Abdon, Hagar R. Shaheen … Seham M. Al Raish
    Studysummary In this review, researchers explore various treatment options for alopecia, focusing on nano-drug delivery systems using plant-based substances, which are potentially effective and less harmful than current treatments, while also highlighting emerging trends such as 3D bioprinting and plant extracts for future therapies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 109

    1. Black Phosphorus Nanosheets Encapsulated Microneedle for Multifunctional Therapy for Androgenic Alopecia Journal of Nanobiotechnology · 2025
    2. Glutamic Acid-Loaded Separable Microneedle Composite for Long-Acting Hair Regeneration Treatment Advanced Composites and Hybrid Materials · 2025
    3. Functional Regeneration Strategies of Hair Follicles: Advances and Challenges Stem Cell Research & Therapy · 2025
    4. 3D Bioprinting of Prefabricated Artificial Skin with Multicomponent Hydrogel for Skin and Hair Follicle Regeneration Theranostics · 2025
    5. An Update on Nanocarriers for Follicular-Targeted Drug Delivery for Androgenetic Alopecia Topical Treatment Expert Opinion on Drug Delivery · 2025
    6. Innovating Alopecia Treatment: Nanostructured Lipid Carriers as Advanced Delivery Platforms Naunyn-Schmiedeberg s Archives of Pharmacology · 2025
    7. Identifying Effective Immune Biomarkers in Alopecia Areata Diagnosis Based on Machine Learning Methods BMC Medical Informatics and Decision Making · 2025
    8. Topical Dutasteride for Androgenic Alopecia: Current State and Prospects Therapeutic Delivery · 2024
    9. A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics ACS Biomaterials Science & Engineering · 2024
    10. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets Molecules/Molecules online/Molecules annual · 2024
    11. Synergistic Treatment of Androgenetic Alopecia with Follicular Co-Delivery of Minoxidil and Cedrol in Metal-Organic Frameworks Stabilized by Covalently Cross-Linked Cyclodextrins International Journal of Pharmaceutics · 2024
    12. The Prediction of Hairfall Pattern in a Person Using Artificial Intelligence for Better Care and Treatment 2024
    13. Cardamonin-Loaded Liposomal Formulation for Improving Percutaneous Penetration and Follicular Delivery for Androgenetic Alopecia Drug Delivery and Translational Research · 2024
    14. An Androgenetic Alopecia Remedy Based on Marine Collagen Peptide-Incorporated Dissolving Microneedles International Journal of Pharmaceutics · 2023
    15. The Role of Exosomes in Follicle Regeneration of Androgenic Alopecia Journal of Drug Delivery Science and Technology · 2023
    16. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    17. Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin Science Advances · 2023
    18. A Review of Herbal Medications for the Treatment of Alopecia International journal of Ayurveda and pharma research · 2023
    19. Novel Treatment of Alopecia Areata With Shooting-Type Candlelit-Dissolving Microneedle Applied materials today · 2023
    20. Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF Journal of Cosmetic Dermatology · 2023
    21. Comparing Current Therapeutic Modalities of Androgenic Alopecia: A Literature Review of Clinical Trials Cureus · 2023
    22. The Effect of an Oral Product Containing Amla Fruit on Female Androgenetic Alopecia: A Randomized Controlled Trial Journal of Ethnopharmacology · 2023
    23. Androgenetic Alopecia: An Update JAAD International · 2023
    24. Protection and Restoration of Damaged Hair via a Polyphenol Complex by Promoting Mechanical Strength, Antistatic, and Ultraviolet Protection Properties Biomimetics · 2023
    25. Activity and Safety of Cinchonine Nanostructured Lipid Carriers as a Hair Growth Stimulant in Mice Model of Androgenetic Alopecia Sains Malaysiana · 2023
    26. Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review Genes · 2023
    27. 3D Bioprinting of Calcium Molybdate Nanoparticles-Containing Immunomodulatory Bioinks for Hair Regrowth Nano today · 2023
    28. Nanotechnology-Based Strategies for Hair Follicle Regeneration in Androgenetic Alopecia 2023
    29. Design and Characterization of Baricitinib Incorporated PLA 3D Printed Pills by Fused Deposition Modeling for Treating Alopecia Areata Polymers · 2023
    30. Formulation Development and Investigations on Therapeutic Potential of Nanogel from Beta Vulgaris L. Extract in Testosterone-Induced Alopecia BioMed Research International · 2023
    31. Efficacy of Low-Level Laser Therapy in Androgenetic Alopecia – A Randomized Controlled Trial International Journal of Trichology · 2023
    32. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    33. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    34. Microneedle Mediated Transdermal Delivery of Beta-Sitosterol Loaded Nanostructured Lipid Nanoparticles for Androgenic Alopecia Drug Delivery · 2022
    35. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and Anti-Hair Loss Effects Pharmaceuticals · 2022
    36. Ayurvedic Management of Alopecia Areata: A Case Report Journal of Ayurveda and Integrative Medicine · 2022
    37. Bioprinting of Hair Follicle Germs for Hair Regenerative Medicine Acta biomaterialia · 2022
    38. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    39. 3D Bioprinting of a Gelatin-Alginate Hydrogel for Tissue-Engineered Hair Follicle Regeneration Acta Biomaterialia · 2022
    40. Utilization of Nanotechnology and Experimental Design in Development and Optimization of Aloe Vera Gel Loaded with Finasteride-Garlic Oil-Nanotransfersomes Journal of Drug Delivery Science and Technology · 2022
    41. Phyllanthus Emblica Extract-Loaded Transfersomes for Hair Follicle Targeting: Phytoconstituents, Characterization, and Hair Growth Promotion Journal of Oleo Science · 2022
    42. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    43. Exploring the Potential of Herbal Drugs for the Treatment of Hair Loss GSC biological and pharmaceutical sciences · 2021
    44. Topical Delivery of Fenugreek Seed Extract Loaded Solid Lipid Nanoparticles Based Hydrogels for Alopecia Journal of pharmaceutical research international · 2021
    45. Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability Molecules · 2021
    46. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    47. Alopecia Types, Current and Future Treatment Journal of dermatology & cosmetology · 2021
    48. Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review Journal of Investigative Dermatology Symposium Proceedings · 2020
    49. Effectiveness, Safety, and Tolerability of Dheedhi Herbal Shampoo Against Alopecia and Seborrheic Dermatitis: A Clinical Perspective Journal of Ayurvedic and herbal medicine · 2020
    50. A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia Natural Products and Bioprospecting · 2020
    51. Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia Pharmaceutics · 2020
    52. Microneedling in Androgenetic Alopecia: Comparing Two Different Depths of Microneedles Journal of Cosmetic Dermatology · 2020
    53. Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall Clinical, cosmetic and investigational dermatology · 2020
    54. The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review PubMed · 2020
    55. Development of Ethosome Comprising Combined Herbal Extracts and Its Effect on Hair Growth Advances in Traditional Medicine · 2020
    56. Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment Polymers · 2020
    57. Hair Care Promising Herbs: A Review Zenodo (CERN European Organization for Nuclear Research) · 2020
    58. Advances in Stem Cell-Based Therapy for Hair Loss PubMed · 2020
    59. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review Skin appendage disorders · 2020
    60. Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells Nutrients · 2019
    61. Phospholipid-Polymer Hybrid Nanoparticle-Mediated Transfollicular Delivery of Quercetin: Prospective Implementation for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2019
    62. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    63. Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead Journal of Maxillofacial and Oral Surgery · 2019
    64. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    65. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    66. Complementary and Alternative Treatments for Alopecia: A Comprehensive Review Skin appendage disorders · 2018
    67. Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata JAMA Dermatology · 2018
    68. Nanoemulsion Vehicles as Carriers for Follicular Delivery of Luteolin ACS Biomaterials Science & Engineering · 2018
    69. Development and Clinical Evaluation of Green Tea Hair Tonic for Greasy Scalp Treatment PubMed · 2018
    70. Valproate: Its Effects on Hair International journal of trichology · 2018
    71. Platelet-Rich Plasma for Androgenic Alopecia Treatment: A Comprehensive Review Dermatology Online Journal · 2018
    72. Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment Journal of Pharmaceutical Sciences · 2017
    73. Experimental and Early Investigational Drugs for Androgenetic Alopecia Expert Opinion on Investigational Drugs · 2017
    74. Impact of Trigonella Foenum-Graecum Leaves Extract on Mice Hair Growth Pakistan Journal of Zoology · 2017
    75. Alopecia Areata of the Beard: A Review of the Literature American Journal of Clinical Dermatology · 2017
    76. Review of Treatment for Alopecia Totalis and Alopecia Universalis International Journal of Dermatology · 2017
    77. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    78. Interventions for Female Pattern Hair Loss JAMA Dermatology · 2017
    79. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health Evidence-based Complementary and Alternative Medicine · 2017
    80. The Wonder of Herbs to Treat Alopecia 2016
    81. Hair Growth Promoting Activity of Cedrol Isolated from the Leaves of Platycladus Orientalis Biomedicine & Pharmacotherapy · 2016
    82. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    83. Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia Drug Development and Industrial Pharmacy · 2015
    84. Hair Restoration Surgery: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2015
    85. Rosemary Oil vs Minoxidil 2% for the Treatment of Androgenetic Alopecia: A Randomized Comparative Trial PubMed · 2015
    86. Hair Growth Promoting Activity of Carthamus Tinctorius Florets Extract-Loaded Nanostructured Lipid Carriers International Journal of Pharmacy and Pharmaceutical Sciences · 2014
    87. Comparative Hair Restorer Efficacy of Medicinal Herb on Nude (Foxn1nu) Mice BioMed Research International · 2014
    88. A Case of Androgenetic Alopecia Treated with Valproic Acid International Journal of Dermatology · 2013
    89. Alopecia Areata Update Dermatologic Clinics · 2012
    90. Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2011
    91. Alopecia Areata: A New Treatment Plan Clinical, cosmetic and investigational dermatology · 2011
    92. Intralesional Steroids for Alopecia Areata International Journal of Trichology · 2010
    93. Topical Immunotherapy in Alopecia Areata International journal of trichology · 2010
    94. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    95. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    96. Hair Growth Promoting Activity of Eclipta Alba in Male Albino Rats Archives of Dermatological Research · 2008
    97. In Vivo Hair Growth Promotion Effects of Cosmetic Preparations Containing Hinokitiol-Loaded Poly(ε-Caprolactone) Nanocapsules Journal of Microencapsulation · 2008
    98. Combination of Topical Garlic Gel and Betamethasone Valerate Cream in the Treatment of Localized Alopecia Areata: A Double-Blind Randomized Controlled Study Indian Journal of Dermatology Venereology and Leprology · 2007
    99. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    100. The Effects of Garlic Topical Gel (5%) in the Treatment of Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2006
    101. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    102. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    103. Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension Journal of Clinical Hypertension · 2004
    104. Pathogenesis of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2004
    105. Onion Juice (Allium Cepa L.), A New Topical Treatment For Alopecia Areata The Journal of Dermatology · 2002
    106. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    107. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    108. Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata Journal of The American Academy of Dermatology · 1987
    109. Large Doses of Glucocorticoid in the Treatment of Alopecia Areata Acta dermato-venereologica · 1975

    Related research 3

    1. Revitalizing Hair Growth: A New Regimen Utilizing Growth Factor Concentrate for Hair Loss Treatment Cureus · 2024
    2. Significant Relationship Between Temporal Hair Loss and Other Scalp Areas in Female Pattern Hair Loss Journal of Dermatology · 2020
    3. The Changing Patterns of Hair Density and Thickness in South Korean Women with Hair Loss: Clinical Office-Based Phototrichogram Analysis International Journal of Dermatology · 2008