Design and Characterization of Baricitinib Incorporated PLA 3D Printed Pills by Fused Deposition Modeling for Treating Alopecia Areata

April 2023 in “ Polymers ”

Mohammed Muqtader Ahmed, Farhat Fatima, Aisha Alnami, Mohammad A. Alsenaidy, Alhussain Aodah, Mohammed F. Aldawsari, Bjad K. Almutairy, Md. Khalid Anwer, Mohammed Jafar

baricitinib alopecia areata fused deposition modeling polylactic acid PLA 3D-printed pills Korsmeyer-Peppas model JAK inhibitor BAB 3DP1 3DP2

TLDR The study created 3D-printed pills that effectively release a hair loss treatment drug over 24 hours.

This study developed and characterized 3D-printed pills incorporating Baricitinib (BAB) using polylactic acid (PLA) filaments through fused deposition modeling (FDM) to treat alopecia areata (AA). The pills, designed with a central hole to enhance drug release, were tested for drug encapsulation, release properties, and stability. Results showed drug release rates of 43.76% and 59.14% over 24 hours for 2% and 4% BAB concentrations, respectively, following the Korsmeyer–Peppas model. The study concluded that these 3D-printed pills could effectively deliver BAB with improved bioavailability and sustained release, offering a low-cost, personalized treatment option for AA.

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