Baricitinib-Loaded Separable Microneedle Array Patch Based on Hyaluronic Acid for Alopecia Areata Therapy

    May 2025 in “ Carbohydrate Polymers ”
    Da In Jeong, Song Yi Lee, Sungyun Kim … Hyun‐Jong Cho
    Studysummary In this study, researchers developed a dissolvable microneedle patch containing baricitinib for alopecia areata treatment, reporting significantly higher hair growth in mouse models compared to controls, suggesting its potential as an effective, pain-free topical therapy.
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    Research cited in this study 17

    1. Effect of Minoxidil Combined With Triamcinolone Acetonide on Alopecia Areata by Microneedle Injection Skin research and technology · 2024
    2. Microneedle Delivery Platform Integrated With Codelivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment ACS Applied Materials & Interfaces · 2024
    3. Dissolving Microneedles for Alopecia Treatment Colloids and surfaces. B, Biointerfaces · 2023
    4. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    5. Safety of Janus Kinase Inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023
    6. Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy ACS Applied Materials & Interfaces · 2023
    7. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    8. Advances in Microneedles Research Based on Promoting Hair Regrowth Journal of Controlled Release · 2022
    9. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    10. Dissolving Microneedles: Applications and Growing Therapeutic Potential Journal of Controlled Release · 2022
    11. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    12. The Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata: A Systematic Review Dermatologic therapy · 2019
    13. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    14. Increased Expression of PD-L1 and PD-L2 in Dermal Fibroblasts From Alopecia Areata Mice Journal of Cellular Physiology · 2017
    15. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    16. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    17. Inhibitory Effect of Tianeptine on Catagen Induction in Alopecia Areata-Like Lesions Induced by Ultrasonic Wave Stress in Mice Clinical and Experimental Dermatology · 2013

    Related research 1

    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019