Baricitinib-Loaded Separable Microneedle Array Patch Based on Hyaluronic Acid for Alopecia Areata Therapy

May 2025 in “ Carbohydrate Polymers ”

Da In Jeong, Song Yi Lee, Sungyun Kim, Seong Jin Jo, Haifeng Yang, Jieun You, ChaeRim Hwang, Ji Won Huh, Yeoung Eun Choi, Wonjun Jo, In‐Jeong Choi, Shunro Matsumoto, Seung‐Ki Baek, Woonsung Na, Jung‐Hwan Park, Hyun‐Jong Cho

baricitinib separable microneedle array patch S-MAP hyaluronic acid alopecia areata topical delivery crystalline baricitinib amorphous state microneedle patch AA

TLDR The new microneedle patch effectively treats alopecia areata with fewer side effects than oral medication.

The study presents a novel separable microneedle array patch (S-MAP) system for delivering baricitinib topically to treat alopecia areata (AA). This system, primarily composed of hyaluronic acid, aims to avoid the systemic side effects associated with oral baricitinib administration. The S-MAP allows for pain-free application and self-medication, transforming crystalline baricitinib into an amorphous state for complete dissolution within 60 minutes. In mouse models, the S-MAP significantly increased hair growth (82%) compared to the control group (31%). The findings suggest that the baricitinib-loaded S-MAP is an efficient and safe alternative to oral formulations for AA therapy, offering targeted delivery with minimized side effects.

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